Y
Yoshihide Tsujimoto
Researcher at Wistar Institute
Publications - 27
Citations - 7923
Yoshihide Tsujimoto is an academic researcher from Wistar Institute. The author has contributed to research in topics: Chromosomal translocation & Gene. The author has an hindex of 23, co-authored 27 publications receiving 7794 citations. Previous affiliations of Yoshihide Tsujimoto include Temple University & University of Pennsylvania.
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Involvement of the bcl-2 gene in human follicular lymphoma
TL;DR: Chromosome 18-specific DNA probes for the areas flanking the breakpoints also detected RNA transcripts 6 kilobases in length in various cell types, and the gene coding for these transcript seems to be interrupted in most cases of follicular lymphomas carrying the t(14;18) chromosomal translocation.
Journal ArticleDOI
Cloning of the chromosome breakpoint of neoplastic B cells with the t(14;18) chromosome translocation
Yoshihide Tsujimoto,Lawrence R. Finger,Jorge J. Yunis,Peter C. Nowell,Carlo M. Croce,Carlo M. Croce +5 more
TL;DR: In this paper, a DNA probe was obtained from an acute B-cell leukemia cell line, which was specific for chromosome 18 and flanked the heavy chain joining region of the immunoglobulin heavy chain locus on chromosome 14.
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Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma.
TL;DR: It is determined that the bcl-2 (B-cell leukemia/lymphoma 2) gene is transcribed into three overlapping mRNAs, and the cDNA clones corresponding to the three bCl-2 transcripts contain at least two exons.
Journal ArticleDOI
Molecular Cloning of the Chromosomal Breakpoint of B-Cell Lymphomas and Leukemias with the t(11;14) Chromosome Translocation
Yoshihide Tsujimoto,Jorge J. Yunis,Louise Onorato-Showe,J Erikson,Peter C. Nowell,Carlo M. Croce +5 more
TL;DR: The chromosomal breakpoint of chronic lymphocytic leukemia (CLL) cells of the B-cell type carrying the translocated long arms of chromosomes 11 and 14 [t(11;14) (q13;q32)] was cloned and a gene, named bcl -1, appears to be unrelated to any of the known retrovirus oncogenes described to date.
Journal ArticleDOI
Clustering of breakpoints on chromosome 11 in human B-cell neoplasms with the t(11;14) chromosome translocation.
Yoshihide Tsujimoto,Elaine S. Jaffe,Jeffrey Cossman,J. Gorham,Peter C. Nowell,Carlo M. Croce +5 more
TL;DR: It is speculated that the t(11 ; 14) chromosome translocation in CLL may be sequence specific and may involve the recombination system for immunoglobulin gene segment (V–D–J) joining.