Y
Yoshiyuki Chiba
Researcher at Osaka University
Publications - 12
Citations - 441
Yoshiyuki Chiba is an academic researcher from Osaka University. The author has contributed to research in topics: Docosahexaenoic acid & Eicosapentaenoic acid. The author has an hindex of 8, co-authored 12 publications receiving 422 citations.
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Journal ArticleDOI
Pluronic F-127 gels incorporating highly purified unsaturated fatty acids for buccal delivery of insulin.
Mariko Morishita,Jose Mario Barichello,Kozo Takayama,Yoshiyuki Chiba,Shinji Tokiwa,Tsuneji Nagai +5 more
TL;DR: The finding demonstrate that 20% PF-127 gels containing unsaturated fatty acids are potential formulations for the buccal delivery of insulin.
Journal ArticleDOI
Enhanced rectal absorption of insulin-loaded Pluronic F-127 gels containing unsaturated fatty acids.
Jose Mario Barichello,Mariko Morishita,Kozo Takayama,Yoshiyuki Chiba,Shinji Tokiwa,Tsuneji Nagai +5 more
TL;DR: The finding demonstrated that 20% PF127 gels containing unsaturated fatty acids are potential formulations for rectal delivery of insulin, indicating that the absorption of insulin occurred very rapidly in the rectum.
Journal ArticleDOI
In vivo effects of highly purified docosahexaenoic acid on rectal insulin absorption.
Yoshinori Onuki,Mariko Morishita,Kozo Takayama,Sinji Tokiwa,Yoshiyuki Chiba,Koichi Isowa,Tsuneji Nagai +6 more
TL;DR: It is demonstrated that DHA has a strong insulin permeability enhancement effect and little toxicity, and is an attractive candidate as an absorption enhancer for intestinal delivery of insulin.
Journal ArticleDOI
Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid.
Atsuyuki Suzuki,Mariko Morishita,Masako Kajita,Kozo Takayama,Koichi Isowa,Yoshiyuki Chiba,Shinji Tokiwa,Tsuneji Nagai +7 more
TL;DR: The results indicate that a W/O/W multiple emulsion incorporating DHA is a possible means of facilitating the intestinal absorption of insulin without inducing any serious damage to the epithelial cells.
Journal ArticleDOI
Docosahexaenoic Acid and Eicosapentaenoic Acid Induce Changes in the Physical Properties of a Lipid Bilayer Model Membrane
TL;DR: Data show that unsaturated fatty acids, particularly DHA and EPA, induce a marked change in the lipid bilayer structure, and it is found that uns saturated fatty acids acted efficiently on the DPPC bilayer, even when incorporated in emulsion form.