Showing papers by "Yoshiyuki Okamoto published in 1996"
TL;DR: A model in vitro drug delivery system based on this type of cleavage with possible applications in the transdermal drug delivery field is developed, which consists of a drug moiety chemically bound by a disulfide bridge to a polymeric backbone, which, once exposed to a predetermined voltage, would cleave the disulfides bond, thereby releasing drug into a soluble medium.
Abstract: A disulfide bond is known to cleave under certain electrochemical conditions. The authors have developed a model in vitro drug delivery system based on this type of cleavage with possible applications in the transdermal drug delivery field. The system consists of a drug moiety chemically bound by a disulfide bridge to a polymeric backbone, which, once exposed to a predetermined voltage, would cleave the disulfide bond, thereby releasing drug into a soluble medium. The fluorescence of the drug was then monitored to ascertain its concentration. The model drug used was 2-mercaptobenzothiazole, a drug reported to exhibit hypoglycemic activity and combat the effects of experimental diabetes. The polymeric backbone used was poly(mercaptopropylmethyl siloxane). A copolymeric prodrug was synthesized using diethylazodicarboxylate (DAD) as a coupling agent in order to give the resulting mercapto/disulfide copolymer of composition 6:4. The disulfide bridge was electrochemically cleaved using an intermittent ...
18 citations