Recent progress in the synthesis of 1,2,3,4,-tetrahydroquinolines

Provided are functionalized silicon compounds and methods for their synthesis and use. The functionalized silicon compounds include at least one activated silicon group and at least one derivatizable functional group. Exemplary derivatizable functional groups include hydroxyl, amino, carboxyl and thiol, as well as modified forms thereof, such as activated or protected forms. The functionalized silicon compounds may be covalently attached to surfaces to form functionalized surfaces which may be used in a wide range of different applications. In one embodiment, the silicon compounds are attached to the surface of a substrate comprising silica, such as a glass substrate, to provide a functionalized surface on the substrate, to which molecules, including polypeptides and nucleic acids, may be attached. In one embodiment, after covalent attachment of a functionalized silicon compound to the surface of a solid silica substrate to form a functionalized coating on the substrate, an array of nucleic acids may be covalently attached to the substrate. Thus, the method permits the formation of high density arrays of nucleic acids immobilized on a substrate, which may be used, for example, in conducting high volume nucleic acid hybridization assays.

Functionalized silicon compounds and methods for their synthesis and use

The chemistry of cyclopropanols

Bromination is one of the most important transformations in organic synthesis and can be carried out using bromine and many other bromo compounds. Use of molecular bromine in organic synthesis is well-known. However, due to the hazardous nature of bromine, enormous growth has been witnessed in the past several decades for the development of solid bromine carriers. This review outlines the use of bromine and different bromo-organic compounds in organic synthesis. The applications of bromine, a total of 107 bromo-organic compounds, 11 other brominating agents, and a few natural bromine sources were incorporated. The scope of these reagents for various organic transformations such as bromination, cohalogenation, oxidation, cyclization, ring-opening reactions, substitution, rearrangement, hydrolysis, catalysis, etc. has been described briefly to highlight important aspects of the bromo-organic compounds in organic synthesis.

Use of Bromine and Bromo-Organic Compounds in Organic Synthesis

This review focuses on the current status and perspectives of the application of polyhedral boron hydrides in medicine. The main topics discussed are boron neutron capture therapy for cancer and radionuclide diagnostics and therapy. X-ray contrast diagnostics, antitumor activity of some metal derivatives of carboranes, and drug design including carborane fragments are discussed as well.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)

Polyhedral Boranes for Medical Applications: Current Status and Perspectives

Determination of the activation parameters of permanent allylic rearrangement in allyl- and methallylboranes and in 1,1-bis(dipropylborylmethyl)ethylene by dynamic NMR spectroscopy

Reductive trans-u,d-diallylation of pyridines, 4,4'-dipyridyl, pyrrole and isoquinoline as well as reductive monoallylation of pyrrole, indole, quinolines, isoquinoline and phenanthridine by allylic boranes were discovered. A convenient method for trans- + cis-isomerization of trans-2,6-diallyl-A3- piperideines and trans-2,5-diallylpylidine was found.

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Reductive mono- and trans-α,α'-diallylation of aromatic nitrogen heterocycles by allylboranes

Reaction of allylboranes with methylcyclopropene

The review presents the following main trends and the perspectives of application of the transition metal clathrochelates in medicine and biochemistry: encapsulation of radioactive metal ion for diagnostics and therapy; imaging agents for MRI; antidotes and prolonged pharmaceuticals; pharmaceuticals for boron neutron capture therapy; antihelminthic and antiparasitic detergents; antioxidants; membrane transport of the metal ions; interaction of the cage metal complexes with nucleic acids and the potential of their self-assembling reactions in immunology and molecular biology (recognition of antibodies, antigens and DNA sites); design of HIV inhibitors for the therapy.

Yu. N. Bubnov

Papers

Determination of the activation parameters of permanent allylic rearrangement in allyl- and methallylboranes and in 1,1-bis(dipropylborylmethyl)ethylene by dynamic NMR spectroscopy

Reductive mono- and trans-α,α'-diallylation of aromatic nitrogen heterocycles by allylboranes

Reaction of allylboranes with methylcyclopropene

Cage complexes of transition metals in biochemistry and medicine

Organoboron compounds. Allylboration of carbonyl compounds with allyl(alkyl)boranes