Electroorganic synthesis has become an established, useful, and environmentally benign alternative to classic organic synthesis for the oxidation or the reduction of organic compounds. In this context, the use of redox mediators to achieve indirect processes is attaining increased significance, since it offers many advantages compared to a direct electrolysis. Kinetic inhibitions that are associated with the electron transfer at the electrode/electrolyte interface, for example, can be eliminated and higher or totally different selectivity can be achieved. In many cases, a mediated electron transfer can occur against a potential gradient, meaning that lower potentials are needed, reducing the probability of undesired side-reactions. In addition, the use of electron transfer mediators can help to avoid electrode passivation resulting from polymer film formation on the electrode surface. Although the principle of indirect electrolysis was established many years ago, new, exciting and useful developments continue to be made. In recent years, several new types of redox mediators have been designed and examined, a process that can be accomplished more efficiently and purposefully using modern computational tools. New protocols including, the development of double mediatory systems in biphasic media, enantioselective mediation and heterogeneous electrocatalysis using immobilized mediators have been established. Furthermore, the understanding of mediated electron transfer reaction mechanisms has advanced. This review describes progress in the field of electroorganic synthesis and summarizes recent advances.

Redox catalysis in organic electrosynthesis: basic principles and recent developments.

While preparative electrolysis of organic molecules has been an active area of research over the past century, modern synthetic chemists have generally been reluctant to adopt this technology. In fact, electrochemical methods possess many benefits over traditional reagent-based transformations, such as high functional group tolerance, mild conditions, and innate scalability and sustainability. In this Outlook we highlight illustrative examples of electrochemical reactions in the context of the synthesis of complex molecules, showcasing the intrinsic benefits of electrochemical reactions versus traditional reagent-based approaches. Our hope is that this field will soon see widespread adoption in the synthetic community.

https://pubsdc3.acs.org/doi/pdf/10.1021/acscentsci.6b00091

Synthetic Organic Electrochemistry: An Enabling and Innately Sustainable Method

Conventional methods for carrying out carbon–hydrogen functionalization and carbon–nitrogen bond formation are typically conducted at elevated temperatures, and rely on expensive catalysts as well as the use of stoichiometric, and perhaps toxic, oxidants. In this regard, electrochemical synthesis has recently been recognized as a sustainable and scalable strategy for the construction of challenging carbon–carbon and carbon–heteroatom bonds. Here, electrosynthesis has proven to be an environmentally benign, highly effective and versatile platform for achieving a wide range of nonclassical bond disconnections via generation of radical intermediates under mild reaction conditions. This review provides an overview on the use of anodic electrochemical methods for expediting the development of carbon–hydrogen functionalization and carbon–nitrogen bond formation strategies. Emphasis is placed on methodology development and mechanistic insight and aims to provide inspiration for future synthetic applications in the field of electrosynthesis.

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Electrochemical strategies for C-H functionalization and C-N bond formation.

N-Oxyl compounds represent a diverse group of reagents that find widespread use as catalysts for the selective oxidation of organic molecules in both laboratory and industrial applications. While turnover of N-oxyl catalysts in oxidation reactions may be accomplished with a variety of stoichiometric oxidants, N-oxyl reagents have also been extensively used as catalysts under electrochemical conditions in the absence of chemical oxidants. Several classes of N-oxyl compounds undergo facile redox reactions at electrode surfaces, enabling them to mediate a wide range of electrosynthetic reactions. Electrochemical studies also provide insights into the structural properties and mechanisms of chemical and electrochemical catalysis by N-oxyl compounds. This review provides a comprehensive survey of the electrochemical properties and electrocatalytic applications of aminoxyls, imidoxyls, and related reagents, of which the two prototypical and widely used examples are 2,2,6,6-tetramethylpiperidine N-oxyl (TEMPO) a...

Tetramethylpiperidine N-Oxyl (TEMPO), Phthalimide N-Oxyl (PINO), and Related N-Oxyl Species: Electrochemical Properties and Their Use in Electrocatalytic Reactions.

While organic electrochemistry can look quite different to a chemist not familiar with the technique, the reactions are at their core organic reactions. As such, they are developed and optimized using the same physical organic chemistry principles employed during the development of any other organic reaction. Certainly, the electron transfer that triggers the reactions can require a consideration of new “wrinkles” to those principles, but those considerations are typically minimal relative to the more traditional approaches needed to manipulate the pathways available to the reactive intermediates formed downstream of that electron transfer. In this review, three very different synthetic challenges—the generation and trapping of radical cations, the development of site-selective reactions on microelectrode arrays, and the optimization of current in a paired electrolysis—are used to illustrate this point.

Using Physical Organic Chemistry To Shape the Course of Electrochemical Reactions.

One-pot electrochemical method of synthesis of ketones, diketones, and esters of monoketo- and diketoalkanoic acids is elaborated. This method is based on the diaphragmless galvanostatic electrolysis of Na salts of secondary nitro compounds—derivatives of nitrohydrocarbons, nitroketones, and esters of nitrated alkanoic acids—in methanol.

Electrolysis of Nitro Compound Salts: Application in Ketone Synthesis

1.

Tert-Butyl hydroperoxide can be used as an initiator of the chain radical reaction for the addition of alcohols to the methyl esters of acrylic and maleic acids.




2.

The decomposition of tert-butyl hydroperoxide in butanol and cyclohexanol at 115° obeys the first-order reaction.




3.

tert-Butyl hydroperoxide in butanol at 115° undergoes mainly induced decomposition, with a small proportion of the decomposition going through the stage of forming the complex with the alcohol.

Initiation of free-radical addition reactions of alcohols by tertiary butyl hydroperoxide

1.

The possibility of using tert-butyl hydroperoxide to initiate the reaction of homolytic alkylation of cycloalkanones with 1-alkenes at temperatures of 100–140° was studied.




2.

Tert-butyl hydroperoxide is analogous to ditert-butyl peroxide in the indicated ability.

Homolytic alkylation of cycloalkanones by 1-alkenes initiated by tertiary-butyl hydroperoxide

1.

The 1-ethyl-3-aeetoxypropyl and 1-ethyl-4-acetoxybutyl radicals were respectively generated by the oxidative decarboxylation of the 2-ethyl-3-acetoxybutanoic and 2-ethyl-4-acetoxypentanoic acids under the influence of lead tetraacetate, and a study was made of their oxidation by the acetate, trifluoroacetate, fluoborate, sulfate, chloride and perchlorate of divalent copper.




2.

Most of the copper salts oxidize the 1-ethyl-3-acetoxypropyl and 1-ethyl-4-acetoxybutyl radicals exclusively to the 2- and 3-pentenyl and the 3- and 4-hexenyl acetates, with the predominant formation of the isomers where the acetoxy group is furthest away from the double bond. Ligands that are coordinated with the copper are practically without effect on the ratio of the formed isomeric alkenyl acetates.

Oxidation of acetoxyalkyl radicals by divalent copper salts

1.

A study was made of the dehydrocarboxylation of some acetoxyalkanoic acids RR'CHCH(COOH) (CH2)nOAc by the joint action of the tetravalent lead and divalent copper acetates in the presence of pyridine.




2.

Conditions were found for running the dehydrocarboxylation that assured a high conversion of the acids to the cis- and trans-acetates RR'CH=CH(CH2)nOAc and RR'CHCH=CH(CH2)n-1OAc.




3.

The mutual arrangement of the acetoxyl and carboxyl groups and the structure of the RR'CH fragment of the acid exert a substantial influence on the ratio of the formed acetates.

Yu. N. Ogibin

Papers

Electrolysis of Nitro Compound Salts: Application in Ketone Synthesis

Initiation of free-radical addition reactions of alcohols by tertiary butyl hydroperoxide

Homolytic alkylation of cycloalkanones by 1-alkenes initiated by tertiary-butyl hydroperoxide

Oxidation of acetoxyalkyl radicals by divalent copper salts

Reactions of carboxylic acids and their derivatives with compounds of variable valence metals