Y
Yubing Lu
Researcher at University of Massachusetts Medical School
Publications - 15
Citations - 1849
Yubing Lu is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Synapse & Cellular differentiation. The author has an hindex of 12, co-authored 14 publications receiving 1597 citations. Previous affiliations of Yubing Lu include University of California, San Francisco.
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Journal ArticleDOI
GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport
Brian D. Freibaum,Yubing Lu,Rodrigo Lopez-Gonzalez,Nam Chul Kim,Sandra Almeida,Kyung-Ha Lee,Nisha M. Badders,Marc Valentine,Bruce L. Miller,Philip C. Wong,Leonard Petrucelli,Hong Joo Kim,Fen-Biao Gao,J. Paul Taylor +13 more
TL;DR: It is shown that a primary consequence of G4C2 repeat expansion is the compromise of nucleocytoplasmic transport through the nuclear pore, revealing a novel mechanism of neurodegeneration.
Journal ArticleDOI
Poly(GR) in C9ORF72-Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons.
Rodrigo Lopez-Gonzalez,Yubing Lu,Tania F. Gendron,Anna Karydas,Helene Tran,Dejun Yang,Leonard Petrucelli,Bruce L. Miller,Sandra Almeida,Fen-Biao Gao +9 more
TL;DR: It is found that DNA damage was greater, in an age-dependent manner, in motor neurons differentiated from iPSCs of multiple C9ORF72 patients than control neurons, revealing another pathogenic mechanism in C9 ORF72-related ALS and FTD.
Journal ArticleDOI
Differential Toxicity of Nuclear RNA Foci versus Dipeptide Repeat Proteins in a Drosophila Model of C9ORF72 FTD/ALS
Helene Tran,Sandra Almeida,Jill Moore,Tania F. Gendron,Uma Devi Chalasani,Yubing Lu,Xing Du,Jeffrey A. Nickerson,Leonard Petrucelli,Zhiping Weng,Fen-Biao Gao +10 more
TL;DR: A Drosophila model expressing 160 G4C2 repeats (160R) flanked by human intronic and exonic sequences is described, finding that nuclear RNA foci are neutral intermediates or possibly neuroprotective through preventing G 4C2 RNA export and subsequent DPR production.
Journal ArticleDOI
Frontotemporal dementia and amyotrophic lateral sclerosis-associated disease protein TDP-43 promotes dendritic branching.
TL;DR: These findings reveal an essential role for TDP-43 in dendritic structural integrity, supporting the notion that loss of normal TTP-43 function in diseased neurons may compromise neuronal connectivity before neuronal cell loss in FTD and ALS.
Journal ArticleDOI
FTD/ALS-associated poly(GR) protein impairs the Notch pathway and is recruited by poly(GA) into cytoplasmic inclusions
TL;DR: The Notch pathway is identified as one of the receptor signaling pathways that might be compromised in C9ORF72 FTD/ALS and the toxicity of (GR)80 and (PR)80 is reported in neuronal and non-neuronal cells in Drosophila.