Due to important role of composite materials in broad spectrum of applications, this article focused on bending and frequency characteristics of a functionally graded graphene platelet (GPL) reinfo...

Parametric study of three-dimensional bending and frequency of FG-GPLRC porous circular and annular plates on different boundary conditions

Recent advances in 3D-printed polylactide and polycaprolactone-based biomaterials for tissue engineering applications.

Geometrically nonlinear free vibration of FG-GPLRC circular plate on the nonlinear elastic foundation

Free vibrational and bending behavior of functionally graded graphene platelet reinforced composite (FG-GPLRC) circular and annular plate with various boundary conditions is studied using the diffe...

Three-Dimensional Static and Free Vibrational Analysis of Graphene Reinforced Composite Circular/Annular Plate Using Differential Quadrature Method

Adding small amounts of carbon nanotubes (CNTs) into the face sheets of sandwich structures can significantly improve their thermo-mechanical responses. However, the formation of CNT clusters, espe...

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Determination of thermoelastic stress wave propagation in nanocomposite sandwich plates reinforced by clusters of carbon nanotubes

This paper deals with the vibration characteristics and nonlinear aeroelastic response of the functionally graded (FG) multilayer composite plate reinforced with graphene nanoplatelets (GPLs) subje...

Vibration, Buckling and Aeroelastic Analyses of Functionally Graded Multilayer Graphene-Nanoplatelets-Reinforced Composite Plates Embedded in Piezoelectric Layers

Thermal-structural analysis for an attitude maneuvering flexible spacecraft under solar radiation

Polycaprolactone (PCL) is a polymer material suitable for being prepared into porous scaffolds used in bone tissue engineering, however, insufficient osteogenic ability and mechanical strength limit its application. Zinc (Zn) alloy with proper mechanical strength and osteogenesis is a promising biodegradable metal that have attracted much attention. Herein, we combined the advantages of PCL and Zn by fabricating PCL/Zn composite scaffolds with different Zn powder contents (1 ​wt%, 2 ​wt%, 3 ​wt%) through fused deposition modelling. The ​mechanical property, cytocompatibility and Zn ​ions release ​behavior of PCL/Zn scaffolds were analyzed ​in vitro. The osteogenesis and osteoclastogenesis properties of the scaffolds were evaluated by being implanted into Sprague-Dawley rats calvaria defect. Results showed that the PCL/Zn scaffolds exhibited improved mechanical properties and cytocompatibility compared with the pure PCL scaffolds. At 8 weeks after in vivo implantaion, the addition of Zn powder promoted new bone formation, in a dose-dependent manner. The scaffolds with 2 ​wt% Zn displayed the best osteogenic effect, while the osteogenic effect was slightly reduced in the scaffolds with 3 ​wt% Zn. In the studied Zn contents, the PCL/Zn scaffolds gradually promoted osteoclastogenesis with increasd Zn content. In the 3 ​wt% Zn group, TRAP-positive cells were observed on the newly formed bone edges around the scaffolds. These dose-dependent effects were verified in vitro using MC3T3-E1 and RAW264.7 ​cells. Finally, we revealed that Zn2+ regulated osteogenesis and osteoclastogenesis by activation of the Wnt/β-catenin and NF-κB signalling pathways, respectively. 

https://doi.org/10.1016/j.mtbio.2021.100202

3D-Printed PCL/Zn scaffolds for bone regeneration with a dose-dependent effect on osteogenesis and osteoclastogenesis

Studies for aeroelastic characteristics and nonlinear response of FG-CNT reinforced composite panel considering the transient heat conduction

Site selection adaptability of traditional villages along rivers can be summarized as the local ecological wisdom accumulated and preserved by generations of villagers. The site selection and distribution pattern of traditional villages is closely related to the river. In this research, 97 traditional villages along the Yellow River in Shanxi and Shaanxi were selected as the research objects. Kernel density analysis, Area density analysis, River buffer zone and a self-designed river location function (RLF) were used to explore, calculate, and evaluate the spatial distribution and site selection adaptation mechanism of traditional villages along the Yellow River. Most traditional villages are located within 15 km buffer area. Villages are densely distributed in one high-density aggregation area and one middle-density aggregation area. The aggregation areas also represent a highest area density of river. The results of RLF show that there are six villages with a value between 1.8 and 2.2, which is consistent with the results of kernel density and river buffer zone analyses. It is concluded that site selection adaptation factors are composed of area density of river, distance from river, river width and bank form. At the same time, it is found that traditional villages are clustered on convex banks, which reflects the scientific value of ancient Chinese feng shuitheory. Our findings improve the understanding of the overall environment and pattern of traditional villages, provide a quantitative basis for the study of site selection adaptability, and offer operational technical guidance for current and future efforts for village renewal, planning, and construction. 

Yuqian Xu

Papers

Vibration, Buckling and Aeroelastic Analyses of Functionally Graded Multilayer Graphene-Nanoplatelets-Reinforced Composite Plates Embedded in Piezoelectric Layers

Thermal-structural analysis for an attitude maneuvering flexible spacecraft under solar radiation

3D-Printed PCL/Zn scaffolds for bone regeneration with a dose-dependent effect on osteogenesis and osteoclastogenesis

Studies for aeroelastic characteristics and nonlinear response of FG-CNT reinforced composite panel considering the transient heat conduction

Spatial distribution and site selection adaptation mechanism of traditional villages along the Yellow River in Shanxi and Shaanxi