Yuri Kaminsky

TL;DR: The results obtained suggest that ammonia‐induced ATP depletion is mediated by activation of the NMDA receptor, which results in decreased protein kinase C‐mediated phosphorylation of Na+,K+‐ATPase and, therefore, increased activity of the ATPase and increased consumption of ATP.

TL;DR: Both reduction of activity of antioxidant enzymes and increased superoxide radical production were prevented by previous injection of 45 mg/kg of nitroarginine, indicating that ammonia induces increased formation of nitric oxide, which in turn reduces the activity of antioxidants enzymes, leading to increased formationof superoxide.

TL;DR: In this paper, a selective antagonist of the N-methyl-D-aspartate type of glutamate receptors was used to prevent death of animals induced by acute ammonia intoxication as well as ammonia-induced depletion of ATP.

TL;DR: It is shown that chronic hyperammonemia markedly prevents the alterations of the contents of energy and ammonia metabolites induced by acute ammonium intoxication and the mitochondrial NAD+/NADH ratio.

TL;DR: The idea that ammonia neurotoxicity does not involve apoptosis is supported and points to impaired p53 transfer from cytoplasm to nuclei as a possible preventer of apoptosis.