Showing papers by "Yutaka Suzuki published in 1976"

Results of Treatment in 320 Patients with Cushing's Syndrome in Japan

Abstract: In 1972 data on 320 patients with Cushing's syndrome were collected from 37 university hospitals and 1 affiliated hospital through/questionaires sent out to them. The data comprised all cases of Cushings' syndrome encountered in each medical center for the 10 years prior to, and including 1972. 113 cases (35.3%) of adenoma, 187 cases (58.4%) of hyperplasia, 16 cases (5.0%) of cancer and 4 cases (1.3%) of ectopic ACTH syndrome comprize the present series. Age and sex distributions of Cushing's syndrome due to adenoma and hyperplasia revealed a definite preponderance of females ranging in age from 20 to 40 years. Over 90% of patients with adenoma were cured by surgical removal of the tumor, compatible with the previously published series and no recurrence was reported. Pituitary irradiation was performed in 65 cases (35%) of hyperplasia as initial therapy or combined therapy with adrenal surgery. Though reserpine was concomitantly administered to a considerable number of cases treated by pituitary irradiation, favourable response was observed in only about 30% of these cases due to hyperplasia with pituitary irradiation. Excellent results (effective in over 90% of cases) were obtained in 53 patients with hyperplasia subjected to bilateral total adrenalectomy, as initial therapy or when other treatments were unsuccessful. Subtotal adrenalectomy or unilateral adrenalectomy revealed much less favourable results, e. g., effective results were obtained in around 60% of cases treated by subtotal adrenalectomy and in only 30% of cases treated by unilateral adrenalectomy. Therapeutic results of patients with hyperplasia treated by subtotal or unilateral adrenalectomy combined with pituitary irradiation surpassed those treated by adrenal surgery alone.