Showing papers by "Yutaka Yamaguchi published in 1974"

A study on focal glomerular lesions found in renal biopsies

Abstract: Focal glomerular lesions were light microscopically found in 32 out of 436 renal biopsies by blind selection. Glomerular lesions in focal distribution are not an independent disease entity and may include a variety of diseases. They may be found in the early stage of some diseases which will progress to a diffuse lesion and also represent defective healing leaving persistent proteinuria or hematuria. The judgement of the presence of focal glomerular lesions should be based on the prominent changes such as nodular segmental mesangial proliferation, adhesions, segmental hyalinosis, organized crescent and localized necrosis. In a very strict sense there were almost no normal glomeruli at the level of electron microscopy. The result of quantitation of mesangial area and nuclear counts suggests that normal appearing glomeruli are not absolutely normal. Serial section study may disclose hidden segmental lesions. The clinical outcome of patients with focal segmental lesions is not simply favorable. Proteinuria or hematuria often perisisrs as long as 10 years or more; however, only a few cases fall into chronic renal failure. Historical background of this condition was also reviewed.