The regenerative materials for hard tissues, i.e. tooth (enamel, dentin, and cementum) and bone, require extremely high standards in terms of their mechanical properties, biocompatibility, bioactivity, and multiple-functionality. Among them, the biomedical materials inspired from various natural proteins have attracted increasing research attention. These blueprint proteins include various hard-tissue-related proteins, such as collagen and non-collagenous proteins (e.g. amelogenin, dentin phosphoprotein, bone sialoprotein, and osteopontin), as well as other natural proteins like mussel foot proteins. The current review highlights the structure–function relationship of protein bioinspired biomedical materials (e.g. polymers and polypeptides) and their applications for tooth and bone regeneration. Specifically, the materials bioinspired from salivary acquired pellicle proteins, which have a strong affinity to hydroxyapatite surfaces, are discussed in detail. Finally, the challenges associated with these protein bioinspired materials and their industrialization potentials are discussed.

Natural protein bioinspired materials for regeneration of hard tissues

Bioinspired and biomimetic micro- and nanostructures in biomedicine.

Fitting pieces into the puzzle: The impact of titanium-based dental implant surface modifications on bacterial accumulation and polymicrobial infections.

Strong and bioactive bioinspired biomaterials, next generation of bone adhesives.

Biomineral interface with superior cell adhesive and antibacterial properties based on enzyme-triggered digestion of saliva acquired pellicle-inspired polypeptide coatings

Z. Luo

Papers

Soybean extract firstly used as a green corrosion inhibitor with high efficacy and yield for carbon steel in acidic medium

Bioinspired from mussel and salivary acquired pellicle: a universal dual-functional polypeptide coating for implant materials