The simultaneous entrapment of biological macromolecules and nanostructured silica-coated magnetite in sol-gel materials using a reverse-micelle technique leads to a bioactive, mechanically stable, nanometer-sized, and magnetically separable particles. These spherical particles have a typical diameter of 53 +/- 4 nm, a large surface area of 330 m(2)/g, an average pore diameter of 1.5 nm, a total pore volume of 1.427 cm(3)/g and a saturated magnetization (M(S)) of 3.2 emu/g. Peroxidase entrapped in these particles shows Michaelis-Mentan kinetics and high activity. The catalytic reaction will take place immediately after adding these particles to the reaction solution. These enzyme entrapping particles catalysts can be easily separated from the reaction mixture by simply using an external magnetic field. Experiments have proved that these catalysts have a long-term stability toward temperature and pH change, as compared to free enzyme molecules. To further prove the application of this novel magnetic biomaterial in analytical chemistry, a magnetic-separation immunoassay system was also developed for the quantitative determination of gentamicin. The calibration for gentamicin has a working range of 200-4000 ng/mL, with a detection limit of 160 ng/mL, which is close to that of the fluorescent polarization immunoassay (FPIA) using the same reactants.

Magnetite-containing spherical silica nanoparticles for biocatalysis and bioseparations （vol 76, pg 1316, 2004）

Metal oxide nanoparticles as antimicrobial agents: a promise for the future

Multidentate unsymmetrically-substituted Schiff bases and their metal complexes: Synthesis, functional materials properties, and applications to catalysis

In the present study, a sustainable green chemistry approach was established to fabricate magnetic Fe3O4 nanoparticles (Fe3O4NPs) using the aqueous fruit extract of edible C guianensis (CGFE) Synthesized NPs were further confirmed with different high-throughput characterization techniques such as UV–visible spectroscopy, FT-IR, XPS, DLS and zeta potential analysis Additionally, XRD, AFM, HRTEM and SQUID VSM demonstrate the generation of crystalline CGFe3O4NPs with mean diameter of 17 ± 10 nm Interestingly, CGFe3O4NPs exhibit a stupendous bactericidal action against different human pathogens which depicts its antimicrobial value A significant dose-dependent cytotoxic effect of CGFe3O4NPs was noticed against treated human hepatocellular carcinoma cells (HepG2)

https://www.tandfonline.com/doi/pdf/10.1080/21691401.2017.1332635

Green synthesis of magnetic Fe3O4 nanoparticles using Couroupita guianensis Aubl. fruit extract for their antibacterial and cytotoxicity activities.

Silica based hybrid materials for drug delivery and bioimaging.

Synthesis, characterization and in vitro antimicrobial activity of some new Schiff bases and their complexes

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Several phthalazine derivatives were synthesized by the one-pot three-component condensation in good to high yields in the presence of diatomite-
 $$\hbox {SO}_{3}\hbox {H}$$
 as a solid acid catalyst. Then, a series (n = 14) of phthalazine sulfonamides were synthesized by the reaction phthalazine sulfonyl chloride and various amines under solvent-free conditions. The prepared compounds were screened for antibacterial activity against Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 5213) as gram negative and positive respectively. Also, in silico physicochemical parameters of synthesized compounds were studied to predict absorption and permeability using Molinspiration online property calculation server. SYNOPSIS A series of phthalazine sulfonamides were synthesized by the reaction phthalazine sulfonyl chloride and various amines under solvent-free conditions by the one-pot three-component condensation in good to high yields in the presence of diatomite-
 $$\hbox {SO}_{3}\hbox {H}$$
 as a solid acid catalyst.

/pdf/synthesis-characterization-and-in-vitro-antibacterial-1mimn08ifb.pdf

Synthesis, characterization and in vitro antibacterial activity of novel phthalazine sulfonamide derivatives

A simple and efficient method for the functionalization of silica-coated Fe3O4 magnetic nanoparticles (Fe3O4@SiO2) using chlorosulfonic acid is described. The prepared compounds were screened for antibacterial activity against Escherichia coli (E. coli ATCC 25922) and Staphylococcus aureus (S. aureus ATCC 25923) under UV-light and dark conditions. It was found that the Fe3O4@SiO2–SO3H was significantly indicated the higher photocatalytic inactivation than both Fe3O4 and Fe3O4@SiO2 against E. coli in compared with S. aureus. Furthermore, the inactivation efficiency against both organisms under light conditions has been higher than this efficiency under dark conditions.

Preparation of Fe3O4 encapsulated-silica sulfonic acid nanoparticles and study of their in vitro antimicrobial activity

Over the last decades, several heterocyclic derivatives compounds have been synthesized or extracted from natural resources and have been tested for their pharmaceutical activities. Xanthene is one of these heterocyclic derivatives. These compounds consist of an oxygen-containing central heterocyclic structure with two more cyclic structures fused to the central cyclic compound. It has been shown that xanthane derivatives are bioactive compounds with diverse activities such as anti-bacterial, anti-fungal, anti-cancer, and anti-inflammatory as well as therapeutic effects on diabetes and Alzheimer. The anti-cancer activity of such compounds has been one of the main research fields in pharmaceutical chemistry. Due to this diverse biological activity, xanthene core derivatives are still an attractive research field for both academia and industry. This review addresses the current finding on the biological activities of xanthene derivatives and discussed in detail some aspects of their structure-activity relationship (SAR).

Zahra Sadat Nazifi

Papers

Synthesis, characterization and in vitro antimicrobial activity of some new Schiff bases and their complexes

Synthesis, characterization and in vitro antibacterial activity of novel phthalazine sulfonamide derivatives

Preparation of Fe3O4 encapsulated-silica sulfonic acid nanoparticles and study of their in vitro antimicrobial activity

Structure-Bioactivity Relationship Study of Xanthene Derivatives: A Brief Review.