Background: The current study was assigned to evaluate the
antioxidant, general toxicity, anti-proliferative and antimicrobial activities
of different extracts obtained from rhizomes of Eremostachys macrophylla
(Lamiaceae).
Methods: All activities were evaluated by obtaining extracts
of E. macrophylla in n-hexane, DCM (dichloromethane) and MeOH (methanol)
by soxhlet apparatus. The antioxidant activity of the extracts was evaluated in
terms of FRST (free radical scavenging activity test) by DPPH (2,
2-diphenyl-1-picrylhydrazyl). BSLT (Brine shrimp lethality tests), MTT (3-[4,
5-dimethylthiazol-2-yl]-2, 5-diphenyltetrazolium bromide) assay and disc
diffusion method were carried out to determine the general toxicity,
anti-proliferative and antibacterial activities of the different extracts,
respectively.
Results: The findings
of the study for antioxidant, anti-proliferative and antibacterial effects
showed that DCM extract was the most active fraction, but n-hexane extract
indicated the most potent effect against Artemia salina.
Conclusion: The results revealed strong bioactive effects of
nonpolar fractions of E. macrophylla rhizomes. Thus, it is possible to
suggest some new potential antioxidant, cytotoxic and antibacterial agents with
no harmful effects on noncancerous cells.

https://ps.tbzmed.ac.ir/PDF/PHARM-23-238.pdf

Bioactive Properties of Eremostachys macrophylla Montbr. & Auch. Rhizomes Growing in Iran

The aim of the present research was to evaluate the antimicrobial potential and phytochemical profile of Eremostachys laciniata plant to look into possible natural therapy agents. The shade-dried whole plant material of Eremostachys laciniata was soaked in methanol for 10 days. The powdered drug was extracted with 80 % methanol three times and filtered at room temperature. The filtrate was evaporated in rotary to get a dark-greenish residue (extract), which was further suspended in water and partitioned successively with n-hexane, chloroform, distill water and n-butanol to obtain nhexane- soluble, chloroform-soluble, distill water-soluble, n-butanol soluble and aqueous fractions, respectively. Different fractions (chloroform, n-hexane, butanol, water and ethyl acetate) of the plant were tested against various bacterial strains namely E.coli, S.aureus, S.typheae, P.auriginosa.The extracted fractions of the plant exhibit moderate activities showing 9mm to 18mm inhibition against different strains of bacteria as compared to the control, which gave maximum inhibition upto 29mm. The Eremostachys laciniata was found to be good source of alkaloids, flavonoids, tennins, resins, carbohydrate, starch, proteins, glycosides, coumarin, terponides, steroids and saponine. Anthranol glycosides were absent in the plant. The above results revealed that Fagonia cretica have an excellent anti-bacterial activity and can be used for disease therapy.

/pdf/antibacterial-and-phytochemical-evaluation-of-the-crude-20k79rdtrs.pdf

Antibacterial and Phytochemical Evaluation of the crude extract and Fractions of Eremostachys laciniata.

The present study evaluated the antifungal activity of honey samples collected from different locations at Khyber Pakhtunkhwa (KPK, Pakistan). Disc diffusion method was used to test the antifungal potential of twenty-one (branded, unbranded, and natural comb) honey samples from the different botanical origins at different concentrations (undiluted, 10%, 30%, and 50%, w/v) against Candida albicans and Rhodotorula species. Branded, unbranded, and natural comb honey samples generate different inhibition zones (4-13 mm, 5-15 mm, and 8-17 mm) against Rhodotorula species. Candida albicans showed resistance for all tested honey samples. Minimum inhibitory concentration (MIC) against Candida albicans and Rhodotorula species were 53.33%-88.12% and 1.76%-90.22% for branded, 61.3% – 93.8% and 9.90% – 95.5% for unbranded, and 67.1%-96.8% and 6.39%-98.8% for natural comb honey. In conclusion, natural comb honey from Khyber Pakhtunkhwa may have antifungal therapeutic potential and could be a useful source for generating functional food.

/pdf/antifungal-activity-of-honey-samples-from-khyber-pakhtunkhwa-3cwhhy11.pdf

Zainab Gul

Papers

Antibacterial and Phytochemical Evaluation of the crude extract and Fractions of Eremostachys laciniata.

Antifungal Activity of Honey Samples from Khyber Pakhtunkhwa (Pakistan) as affected by Botanical Origin

Synthesis, β-Glucuronidase Inhibitory Activity, and Molecular Docking Study of Oxazole Derivatives