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Zbigniew A. Cichacz
Researcher at Arizona State University
Publications - 41
Citations - 1702
Zbigniew A. Cichacz is an academic researcher from Arizona State University. The author has contributed to research in topics: Spongistatin & Spongia. The author has an hindex of 24, co-authored 41 publications receiving 1645 citations. Previous affiliations of Zbigniew A. Cichacz include University of Arizona & Arizona's Public Universities.
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Isolation and Structure of Spongistatin 1
TL;DR: An Eastern Indian Ocean marine sponge in the genus onaia was located in the Republic of the Maldives and found to contain a structurally unprecedented macrocyclic lactone named spongistatin 1 as discussed by the authors.
Journal ArticleDOI
Isolation and structure of the cancer cell growth inhibitor dictyostatin 1
TL;DR: Dictyostatin 1 2, a new type of macrocyclic lactone bearing a 22-membered ring system, has been isolated from a Republic of Maldives marine sponge and found to strongly inhibit growth of the murine P388 lymphocytic leukaemia.
Journal Article
Spongistatin 1, a highly cytotoxic, sponge-derived, marine natural product that inhibits mitosis, microtubule assembly, and the binding of vinblastine to tubulin.
TL;DR: A new member of the group of complex natural products that inhibit mitosis by binding in the Vinca alkaloid domain of tubulin is isolated from a Spongia species and named spongistatin 1.
Journal ArticleDOI
The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain.
Ruoli Bai,George F. Taylor,Zbigniew A. Cichacz,Cherry L. Herald,John A. Kepler,George R. Pettit,Ernest Hamel +6 more
TL;DR: The highly cytotoxic, sponge-derived, antimitotic macrolide polyether spongistatin 1 has been previously shown to inhibit microtubule assembly, the binding of vinblastine and GTP to tubulin, and displacement of GDP bound in the exchangeable site of tubulin.