Ze-Qi Xu

TL;DR: Substantial in vitro evidence has demonstrated that betulinic acid is effective against small- and non-small-cell lung, ovarian, cervical, and head and neck carcinomas and potential mechanisms of action may enable this agent to be effective in cells resistant to other chemotherapeutic agents.

TL;DR: This review provides an overview of recent R&D activities in the search for novel antibiotics against MDR Gram-negatives and examines new analogs of existing antibiotic molecules as well as agents against novel bacterial targets such as aminoacyl–tRNA synthetase and peptide deformylase.

TL;DR: Levels of (+)-calanolide A in human plasma were higher than would have been predicted from animal studies, yet the safety profile remained benign, and although raw plasma drug levels were higher in women than in men, when doses were normalized for body mass, the pharmacokinetic profiles were virtually identical with those observed for males.

TL;DR: Pyranocoumarin compounds were identified to embody a novel and unique pharmacophore for anti-TB activity and three of the four bactericidal compounds were amino derivatives, with MIC values of 16 microg/mL and respective MBC values of 32, 32, and 64 microg /mL.

TL;DR: The Wittig reagent [(diethoxyphosphinyl)methylidene]triphenylphosphorane (1b) has been successfully synthesized for the first time via its phosphonium triflate salt (4a) by treating (dieth Oxyphosph Vinyl)methyl triflated with triphenylPhosphine, enabling the corresponding alpha,beta-unsaturated phosphonates.