The invention relates to a bufo melanostictus antioxidative peptide and its gene and an application in pharmacy. The bufo melanostictus antioxidative peptide is cyclic peptide consisting of 33 amino acids, the molecular weight is 3678.14 Dalton, and the isoelectric point is 10.33, and the amino acid sequence is shown as SEQ ID NO.1; the third cysteine and the eighth cysteine of the polypeptide are formed to be an intramolecular disulfide bond. The gene sequence of the bufo melanostictus antioxidative peptide consists of SEQ ID NO.4, wherein the matured bufo melanostictus antioxidative peptide encoded with functions is the 394-492 bit of nucleotide. The matured functional polypeptide amino acid sequence is deduced by gene of bufo melanostictus antioxidative peptide; the compounded bufo melanostictus antioxidative peptide has very strong agglutinin, serine protease inhibitor and antioxygenation.

Zhang Bei

Papers

Bufo melanostictus antioxidative peptide and its gene and application in pharmacy