Z
Zhenyu Diao
Researcher at Nanjing University
Publications - 39
Citations - 934
Zhenyu Diao is an academic researcher from Nanjing University. The author has contributed to research in topics: Decidualization & Medicine. The author has an hindex of 14, co-authored 32 publications receiving 704 citations.
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Journal ArticleDOI
MicroRNA-155 contributes to preeclampsia by down-regulating CYR61.
Yanqing Zhang,Zhenyu Diao,Li Su,Haixiang Sun,Ruotian Li,Hengmi Cui,Hengmi Cui,Yali Hu,Yali Hu +8 more
TL;DR: It is reported for the first time that overexpression of miR-155 contributes to PE development by targeting and down-regulating angiogenic regulating factor CYR61, leading to pathological alterations.
Journal ArticleDOI
MicroRNA-155 inhibits proliferation and migration of human extravillous trophoblast derived HTR-8/SVneo cells via down-regulating cyclin D1
TL;DR: It is found that cyclin D1 may be a target of miR-155 in HTR-8/SVneo cells, and a negative regulatory role of miD1/p27 pathway in proliferation and migration of the cells is demonstrated.
Journal ArticleDOI
Curcumin improves LPS-induced preeclampsia-like phenotype in rat by inhibiting the TLR4 signaling pathway.
Ping Gong,Mo Liu,Guomin Hong,Yujing Li,Pingping Xue,Mingming Zheng,Mengfei Wu,Li Shen,Muyi Yang,Zhenyu Diao,Yali Hu +10 more
TL;DR: Curcumin improves the PE-like phenotype in rat model by reducing abnormal inflammation related to TLR4 signaling pathway, and deficient trophoblast invasion and spiral artery remodeling induced by LPS were improved by curcumin.
Journal ArticleDOI
Single administration of ultra-low-dose lipopolysaccharide in rat early pregnancy induces TLR4 activation in the placenta contributing to preeclampsia.
Pingping Xue,Mingming Zheng,Ping Gong,Caimei Lin,Jianjun Zhou,Yujing Li,Li Shen,Zhenyu Diao,Guijun Yan,Haixiang Sun,Yali Hu +10 more
TL;DR: LPS administration to pregnant rats in early pregnancy could elicit TLR4-mediated immune response at the maternal-fetal interface contributing to poor early placentation that may culminate in the preeclampsia-like syndrome.
Journal ArticleDOI
MicroRNA-155 is involved in the remodelling of human-trophoblast-derived HTR-8/SVneo cells induced by lipopolysaccharides.
TL;DR: LPS may induce remodelling of the human-trophoblast-derived HTR-8/SVneo cells by increasing miR-155, acting in part through the AP-1 and NF-κB pathways.