Arbutin protects brain against middle cerebral artery occlusion-reperfusion (MCAo/R) injury.

Big data is typically characterized with 4V’s: Volume, Velocity, Variety and Veracity. When it comes to big graphs, these challenges become even more staggering. Each and every of the 4V’s raises new questions, from theory to systems and practice. Is it possible to parallelize sequential graph algorithms and guarantee the correctness of the parallelized computations? Given a computational problem, does there exist a parallel algorithm for it that guarantees to reduce parallel runtime when more machines are used? Is there a systematic method for developing incremental algorithms with effectiveness guarantees in response to frequent updates? Is it possible to write queries across relational databases and semistructured graphs in SQL? Can we unify logic rules and machine learning, to improve the quality of graph-structured data, and deduce associations between entities? This paper aims to incite interest and curiosity in these topics. It raises as many questions as it answers.

Big Graphs: Challenges and Opportunities

Adenosinergic Pathway in Parkinson’s Disease: Recent Advances and Therapeutic Perspective

Objective To explore the effects of pramipexole combined with nerve growth factor (NGF) on cognitive impairment and urinary Alzheimer-associated neural thread protein (AD7c-NTP) expression in patients with Parkinson's disease (PD). Methods Fifty patients with PD treated in our hospital from February 2020 to April 2021 were enrolled. The patients were arbitrarily assigned into control group and study group. The former was treated with pramipexole, and the latter was treated with pramipexole combined with NGF. The efficacy, cognitive function, serum inflammatory factors, cortisol levels, serum macrophage migration inhibitory factor (MIF), brain-derived neurotrophic factor (BDNF), urine AD7c-NTP levels, and the incidence of adverse reactions were compared. Results First of all, the effective rate in the study group was higher compared to the control group (P < 0.05). After treatment, the cognitive function was enhanced, and the scores of Montreal cognitive assessment (MoCA) in the study group were higher compared to the control group (P < 0.05). The levels of serum IL-6, CRP, and TNF-α decreased after treatment, and the levels of serum IL-6, CRP, and TNF-α in the study group were remarkably lower compared to the control group (P < 0.05). In addition, the levels of serum DA, NE, and 5-HT increased after treatment, and the levels of serum DA, NE, and 5-HT in the study group were remarkably higher compared to the control group (P < 0.05). Then, the levels of serum MIF and urine AD7c-NTP decreased and BDNF increased after treatment, and the level of BDNF in the study group was higher compared to the control group, while the levels of serum MIF and urine AD7c-NTP in the study group were lower compared to the control group (P < 0.05). Finally, the adverse reactions were compared. The incidence of adverse reactions in the study group was lower compared to the control group, and the difference exhibited not statistically significant (16.00% vs. 24.00%, P > 0.05). Conclusion Pramipexole combined with NGF therapy not only can effectively strengthen the cognitive impairment of patients with PD and promote clinical efficacy and high safety but also can inhibit inflammatory state, regulate brain neurotransmitters, and reduce urinary AD7c-NTP levels.

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Zhihai Yuan

Papers

Arbutin effectively ameliorates the symptoms of Parkinson's disease: the role of adenosine receptors and cyclic adenosine monophosphate.