Z
Zhiping Ruan
Researcher at Xi'an Jiaotong University
Publications - 59
Citations - 1081
Zhiping Ruan is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 17, co-authored 44 publications receiving 744 citations.
Papers
More filters
Journal ArticleDOI
Efficacy and safety of gemcitabine-oxaliplatin combined with huachansu in patients with advanced gallbladder carcinoma.
TL;DR: GEMOX combined with huachansu (cinobufagin) injection is well tolerated, effective, thus improving the quality of life of patients with advanced GBC, and the QOL of patients was improved after chemotherapy.
Journal ArticleDOI
PTEN regulates angiogenesis and VEGF expression through phosphatase-dependent and -independent mechanisms in HepG2 cells
TL;DR: This study suggests the novel viewpoint that PTEN suppresses angiogenesis and VEGF expression in HCC through both phosphatase-dependent and -independent mechanisms.
Journal ArticleDOI
PTEN inhibits the migration and invasion of HepG2 cells by coordinately decreasing MMP expression via the PI3K/Akt pathway.
TL;DR: The data show that PTEN not only inhibits HepG2 cell growth via cell cycle arrest, but also suppresses cell invasion in a PI3K/Akt/MMP-dependent manner, which suggests that loss or mutation of PTEN may contribute to increased cell invasion and facilitates HCC progression.
Journal ArticleDOI
Implications of biomarkers in human hepatocellular carcinoma pathogenesis and therapy.
TL;DR: This review will focus on the role of several specific biomarkers implicated in the pathogenesis of HCC and several promising molecular-targeted drugs that target the biomarkers of H CC.
Journal ArticleDOI
Polycomb complex protein BMI-1 promotes invasion and metastasis of pancreatic cancer stem cells by activating PI3K/AKT signaling, an ex vivo, in vitro, and in vivo study.
Min-Cong Wang,Min Jiao,Tao Wu,Li Jing,Jie Cui,Hui Guo,Tao Tian,Zhiping Ruan,Yongchang Wei,Lili Jiang,Hai-Feng Sun,Lan‐xuan Huang,Kejun Nan,Chun-Li Li +13 more
TL;DR: The found that up-regulated expression of BMI-1 was associated with tumor invasion, metastasis and poor survival of pancreatic cancer patients and it was identified that BMI- 1 expression activating PI3K/AKT singing pathway by negative regulating PTEN was the main mechanism of promoting invasion and metastasis ability of Pancic CSCs.