Prognostic analysis for patient survival often employs gene expressions obtained from high-throughput screening for tumor tissues from patients. When dealing with survival data, a dependent censoring phenomenon arises, and thus the traditional Cox model may not correctly identify the effect of each gene. A copula-based gene selection model can effectively adjust for dependent censoring, yielding a multi-gene predictor for survival prognosis. However, methods to assess the impact of various types of dependent censoring on the multi-gene predictor have not been developed. In this article, we propose a sensitivity analysis method using the copula-graphic estimator under dependent censoring, and implement relevant methods in the R package “compound.Cox”. The purpose of the proposed method is to investigate the sensitivity of the multi-gene predictor to a variety of dependent censoring mechanisms. In order to make the proposed sensitivity analysis practical, we develop a web application. We apply the proposed method and the web application to a lung cancer dataset. We provide a template file so that developers can modify the template to establish their own web applications.

/pdf/sensitivity-analysis-for-survival-prognostic-prediction-with-3qgnuaqq.pdf

Sensitivity Analysis for Survival Prognostic Prediction with Gene Selection: A Copula Method for Dependent Censoring

The additive hazard regression model plays an important role when the excess risk is the quantity of interest compared to the relative risks, where the proportional hazard model is better. This paper discusses parametric regression analysis of survival data using the additive hazards model with competing risks in the presence of independent right censoring. In this paper, the baseline hazard function is parameterized using a modified Weibull distribution as a lifetime model. The model parameters are estimated using maximum likelihood and Bayesian estimation methods. We also derive the asymptotic confidence interval and the Bayes credible interval of the unknown parameters. The finite sample behaviour of the proposed estimators is investigated through a Monte Carlo simulation study. The proposed model is applied to liver transplant data.

https://www.mdpi.com/2073-8994/15/2/485/pdf?version=1676971075

Estimation of the Modified Weibull Additive Hazards Regression Model under Competing Risks

In this paper, a competing risks model with dependent causes of failure is considered under left-truncated and right-censoring scenario. When the dependent failure causes follow a Marshall–Olkin bivariate exponential distribution, estimation of model parameters and reliability indices are proposed from classic and Bayesian approaches, respectively. Maximum likelihood estimators and approximate confidence intervals are constructed, and conventional Bayesian point and interval estimations are discussed as well. In addition, E-Bayesian estimators are proposed and their asymptotic behaviors have been investigated. Further, another objective-Bayesian analysis is also proposed when a noninformative probability matching prior is used. Finally, extensive simulation studies are carried out to investigate the performance of different methods. Two real data examples are presented to illustrate the applicability.

/pdf/reliability-estimation-for-dependent-left-truncated-and-1nu1asnh.pdf

Zhiyuan Zuo

Papers

Reliability Estimation for Dependent Left-Truncated and Right-Censored Competing Risks Data with Illustrations