Showing papers by "Atlantic Health System published in 1998"
TL;DR: Dual-site right atrial pacing is safe, achieves long-term rhythm control in most patients, decreases the need for cardioversion, and antithrombotic therapy can be selectively reduced.
244 citations
Journal Article•
TL;DR: This review has attempted to provide a rationale approach to the decision process to permit a hypertensive child to partake in leisure and competitive sports and emphasizes four major areas of associated pediatric hypertension.
14 citations
12 citations
Journal Article•
TL;DR: The change agent is a necessity rather than an option for a hospital's future success in the volatile managed care environment as discussed by the authors, while his or her message may be unpopular and tactics unconventional, the change agent had extraordinary confidence and capacity to move an organization from analysis to synthesis.
Abstract: The change agent is a necessity rather than an option for a hospital's future success in the volatile managed care environment. While his or her message may be unpopular and tactics unconventional, the change agent had the extraordinary confidence and capacity to move an organization from analysis to synthesis. This article describes the change agent's makeup and method of operation as well as the 10 most potent tools and insights for effecting sustainable change.
5 citations
TL;DR: The preliminary results of the Asian-Oceanian Clinical Oncology Association’s randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma are reported, and the authors report no significant gain in relapse free and overall survival with the addition of neoadjuvant chemotherapy.
Abstract: Nasopharyngeal carcinoma holds an important place in the debate regarding whether adjuvant chemotherapy is beneficial in the treatment of head and neck cancers. This is because 1) nasopharyngeal carcinoma is a very chemoresponsive tumor, and there are reports of long-standing complete responses for patients with distant metastasis who are given adequate chemotherapies; 2) of all the squamous cell carcinomas of the head and neck, nasopharyngeal carcinoma has the highest incidence (30 – 40%) of distant metastasis; and 3) numerous retrospective or single-arm studies have reported excellent and promising results with the addition of chemotherapy in the treatment of nasopharyngeal carcinoma. Because the theoretic basis of neoadjuvant chemotherapy is to enhance locoregional control by tumor debulking or sensitizing the tumor to radiation and to decrease distant metastasis by treating occult micrometastasis, nasopharyngeal carcinoma appears to be the perfect head and neck malignancy for chemotherapy to display its potential, given the considerations just listed. In this issue of Cancer, Chua et al. report the preliminary results of the Asian-Oceanian Clinical Oncology Association’s randomized trial comparing cisplatin and epirubicin followed by radiotherapy versus radiotherapy alone in the treatment of patients with locoregionally advanced nasopharyngeal carcinoma. The authors reported no significant gain in relapse free and overall survival with the addition of neoadjuvant chemotherapy and concluded that they could not recommend the routine administration of neoadjuvant chemotherapy for this group of patients. The results and conclusion of this article will surely add to the current debate regarding the role of chemotherapy in the treatment of nasopharyngeal carcinoma and possibly other head and neck cancers. This article is important because of 1) the large number of patients involved and 2) the small number of centers involved, which indicate that the physicians are familiar with the disease. Given the recent publication from the Intergroup Study, many physicians in the Western Hemisphere had accepted the importance of chemotherapy in the treatment of nasopharyngeal carcinoma. However, as this article’s data and the data from the International Nasopharynx Can2255
5 citations