Showing papers by "Jordan University of Science and Technology published in 1968"

Intracavitary Thiotepa in Malignant Pleural and Peritoneal Effusions

Abstract: A number of methods for controlling the exudation in serous cavities, in the palliative treatment of cases of effusions of malignant origin, have been introduced during the past two decades. Resort had previously to be made to frequent paracenteses, sometimes supplemented by roentgen irradiation to large thoracic or abdominal fields. Radiotherapy frequently caused severe side reactions, and its effect was often poor. Hormonal therapy was only occasionally beneficial. Intracavitary application of radioactive isotopes was introduced in 1945 by MULLER who used 63Zn and later (1950) 198Au. Numerous reports have since been published, inter alios, by DENNIS et coll. (1956), HANSEN & HAUG (1960), and LAMBRETHSEN & SELL (1961) on favourable results with 19sAu, the exudation ceasing or being reduced in 50 to 70 per cent of the cases. However, this treatment has the drawback of requiring specially trained staff which will be exposed to a certain amount of radiation even with the best apparatus. Furthermore, it is rather costly and not suited for ambulatory use. CLADIO & PERCESEPE (1958) employed prednisolone intrapleurally in a