Showing papers by "Mahatma Gandhi Memorial Medical College published in 2011"
TL;DR: The new aceclofenac-CR formulation was found to be effective and safe while offering practical advantage of once daily administration and similar in terms of efficacy as conventional acecl ofenac in knee OA patients with fewer adverse events.
18 citations
TL;DR: Renal arterial thrombosis because of blunt abdominal trauma is still an underreported entity, treatment for which has not yet been established, and both early nephrectomy and delayed revascularization are not justified treatment options.
Abstract: Background: Isolated renal trauma in case of blunt trauma abdomen (BTA) is not common. Renal artery occlusion by thrombosis in such cases is seen very rarely. These cases had been traditionally treated by early nephrectomy, but nowadays, renal preservation is considered whenever possible. Treatment options to do so are being developed. Methods: Recently we came across one such case of isolated unilateral renal artery thrombosis (RAT) because of BTA. Relevant literature especially on various therapeutic techniques has been critically reviewed briefly along with case presentation. Results: Isolated blunt traumatic RAT has an incidence of less than 1%. Only about 400 cases have been reported. It must be diagnosed and treated as soon as possible to avoid progressive permanent loss of renal function. Contrast-enhanced CT scanning is the preferred modality for evaluation and follow-up of RAT. Conservative treatment is reserved for unilateral cases. For bilateral cases and when RAT occurs in a solitary kidney, revascularization either surgically or more preferably by less invasive percutaneous techniques has been recommended. Conclusion: Renal arterial thrombosis because of blunt abdominal trauma is still an underreported entity, treatment for which has not yet been established. Both early nephrectomy and delayed revascularization are not justified treatment options.
14 citations
TL;DR: The effects of atropine, hyoscine and the total alkaloids of Datura alba on the content of rat brain are reported.
Abstract: Sm,-The central stimulatory actions of atropine in high doses causing excitement, tremors and hallucinations are well known. These actions in relation to brain acetylcholine (Giarman & Pepeu, 1964) and cholinesterase (Lullmann, Forster & Westerman, 1952) have been investigated. Some similarities in the actions of atropine and lysergic acid diethylamide (LSD) like facial flush, hyperthermia, rise in blood pressure and mydriasis are known (Pfeiffer, 1959). Further, LSD has been shown to cause an increase in the 5-HT content of rat brain (Freedman, 1961 ; Freedman & Giarman, 1962). We now report the effects of atropine, hyoscine and the total alkaloids of Datura alba on the ~ H T content of rat brain. Adult albino rats, 100-150 g, were injected intraperitoneally with the drugs (25 mg/kg) in 0.5 ml of 0.9% saline. Control animals had normal saline only. The rats were killed + hr after the administration of drugs and the brain (excluding the olfactory lobe, cerebellum and pituitary glands) removed quickly. The
1 citations