Showing papers by "Medical University of Varna published in 2005"
TL;DR: Health education on the established causes of stroke is an urgent priority in Bulgaria and stress and poverty accounted for 69% of the first mentions in 2000 and 59% in 2003.
Abstract: Background: Knowledge of stroke risk factors is undocumented in Bulgaria. Methods: 188 subjects in 2000 and 447 in 2003 were asked: ‘Why do you think stroke is so common in this region?’ Results: Stress and poverty accounted for 69% of the first mentions in 2000 and 59% in 2003. There were no mentions of high blood pressure and no first mentions of smoking in 2000. High blood pressure appears only 10 times and smoking 12 times among 745 answers in 2003. Conclusion: Health education on the established causes of stroke is an urgent priority in Bulgaria.
17 citations
TL;DR: Assuming that the pathogenesis of inflammation-related diseases such as atherosclerosis, thyroid-associated ophthalmopathy, inflammatory bowel diseases, and breast cancer may be influenced by competing stimulatory and inhibitory effects mediated by adipokines, this concept may reveal new tools for the development of adipopharmacology of inflammatory disease.
Abstract: Besides its importance for glucose, lipid and energy metabolism, the present paradigm defines adipose tissue as thebody's largest endocrine and paracrine organ. Accumulating evidence demonstrates that adipose tissue cells synthesize and release a large number of signaling proteins collectively termed adipokines. Adipokines regulate a broad spectrum of biological processes, with inflammation being a key example. This defines a new field of study: adipobiology of inflammation. Herewe shalldance round it, supposing that the pathogenesis of inflammation-related diseases such as atherosclerosis, thyroid-associated ophthalmopathy, inflammatory bowel diseases, and breast cancer may be influenced by competing stimulatory and inhibitory effects mediated by adipokines. This concept may reveal new tools for the development of adipopharmacology of inflammatory disease. Biomedical Reviews 2005; 16: 83-88.
7 citations
TL;DR: For example, this paper found that brain ischemia is a major activator of these precursors as demonstrated by experimental models in rodents and monkeys, while in rodents, postischemic progenitor cell activation was at lower levels than in rodents.
Abstract: The adult mammalian hippocampus harbors neural precursor cells capable of generating glial and neuronal cells. Their existence was demonstrated in both non-primate mammals and primates including humans, and recently has attracted a significant scientific interest focused on the precursor cell potential to replace lost brain cells. Proliferation and differentiation of hippocampal progenitors are affected by brain injury and are regulated by a variety of molecular signals. Brain ischemia is a major activator of these precursors as demonstrated by experimental models in rodents and monkeys. In rodent hippocampal formation, ischemia increases neurogenesis and gliogenesis in both dentate gyrus and cornu Ammonis. In monkeys, however, ischemia was unable to trigger production of new neurons in cornu Ammonis, while in dentate gyrus postischemic progenitor cell activation was at lower levels than in rodents. Thus, rodents and primates appear to differ in their precursor cells` ability to perform neurogenesis. Unraveling the molecular machinery responsible for this interspecies discrepancy might reveal novel strategies to manipulate neural precursors for therapeutic purposes in humans. Biomedical Reviews 2005; 16: 1-11.
4 citations