Showing papers by "Renji Hospital published in 1992"
TL;DR: The results of the present study clearly suggest that the status of the lower part of the stereocilia and the continuity of the cuticular plate play an important role in determining the reversibility of threshold shifts.
67 citations
Journal Article•
TL;DR: It is concluded that this hemiparkinsonian model of rhesus monkey will be of value in the elucidation of the neural mechanism underlying L-DOPA or DA agonist induced dyskinesia in Parkinson's disease and in the search for newer methods of treatment which would produce less dyskine and response fluctuations.
Abstract: Infusion of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) into the right common carotid artery of 5 rhesus monkeys produced hemiparkinsonian syndrome in the contralateral limbs which responded to madopa or apomorphine therapy. Moreover, these two drugs induced circling away from the MPTP-treated side, amphetamine induced rotation toward the MPTP-treated side. Long-term use of madopa developed a peak-dose dyskinesia of the face and the limbs contralateral to the MPTP-treated side. The ipsilateral toxic effects were confirmed biochemically by reduction of nigrostriatal DA and histologically by degeneration of nigral neurons of the MPTP-treated side. It is concluded that this hemiparkinsonian model of rhesus monkey will be of value in the elucidation of the neural mechanism underlying L-DOPA or DA agonist induced dyskinesia in Parkinson's disease and in the search for newer methods of treatment which would produce less dyskinesia and response fluctuations.
1 citations
TL;DR: The alternate chemotherapy with RA for post- induction remission therapy could be useful to improve long-term survivors and to prolong the duration of remission.
Abstract: As to determine the effect of post-remission therapy in prolonging survival and duration of remission after complete remission, 50 patients with APL in complete remission induced by retinoic acid (RA) were divided into three groups randomly: (A) 30 cases, treated by alternate chemotherapy with RA; (B) 10 cases, with RA alone; (C) 10 cases, only with chemotherapy. The survival curves showed that Group A had the survival time more than 1 year in 87.4%, more than 2 year in 80.7%. 26/30 cases were survival and still in remission, the survival curve tend to be a plateau at 16 months. In Group B more than 1 year in 45.7%. In Group C, more than 1 year in 50%. (Keplan-Meier χ2=8.93P<0.01). This result showed that the alternate chemotherapy with RA for post- induction remission therapy could be useful to improve long-term survivors and to prolong the duration of remission.
1 citations
TL;DR: In this paper, the authors describe the ablative effect of argon laser light, delivered fibre optically in vitro, on 234 segments of atherosclerotic human aorta.
Abstract: This paper describes the ablative effect of argon laser light, delivered fibre optically in vitro, on 234 segments of atherosclerotic human aorta Variables such as energy density, type of atheroma and immersion media were taken into account All irradiated specimens were subsequently submitted to histological examination and crater volumes in mm3 were derived from micrometer measurements made at light microscopy Results showed: (1) a linear relationship between energy dose and crater volume in fibrous atheroma; (2) significantly greater surrounding tissue damage in the higher energy dose groups; (3) a lower dose response in calcified tissue than in fatty streaks or fibrous atheroma; (4) immersion of tissue in blood during ablation resulted in a significantly greater dose response than immersion in plasma or saline, and the corresponding surrounding tissue damage was greatest under blood Thus, argon laser light is both effective and predictable in response when ablating atheromatous tissue, and the efficiency of the process depends on the immersion medium The degree of surrounding tissue damage depends on the energy dose