Showing papers by "Roussel Uclaf published in 1966"

9-isopropylidenyl-9,10-dihydro-anthracene-10-carboxylic acid esters

Abstract: Novel compounds of the general formula (in which R1 and R2, which may be the same or different, represent alkyl groups contain 1-5 carbon atoms) are obtained by condensing 9 - isopropylidene - 9,10 - dihydroanthracene - 10-carboxylic acid chloride with a b -aminoethanol of the formula wherein R1 and R2 are as defined above, e.g. b -dimethylamino-, b -diethylamino-, b -methylethylamino-, b -methylbutylamino-, b -methylisopropylamino or b -ethylbutylaminoethanol. The products form non-toxic acid addition salts. 9 - Isopropylidene - 9,10 - dihydroanthracene - 10 - carboxylic acid chloride is obtained from the corresponding acid with a dehydrating agent, e.g. thionyl chloride, phosphorus trichloride or phosphorus pentachloride. Pharmaceutical compositions containing the above novel compounds and having a spasmolytic activity are administered orally, parenterally, or rectally.

1,3-thiazines and their preparation

Abstract: LACTONES OF 2-(CARBONYL-AMINO-METHYL)-5-HYDROXYMETHYL-3,6-DIHYDRO-2H-1,3-THIAZINE-4 -CARBOXYLIC ACIDS USEFUL AS INTERMEDIATES FOR ANTIBIOTICS OF THE C-CEPHALOSPORINE FAMILY AND THEIR PREPARATION. THE INVENTION RELATES TO NOVEL DIHYDRO-1,3-THIAZINE COMPOUNDS OF THE FORMULA 2-(R-OOC-CH(-Y)-),7-(O=)-1,2,5,7-TETRAHYDRO-4H-FURO(3,4-D) (3,1)THIAZINE WHEREIN R IS SELECTED FROM THE GROUP CONSISTING OF ALKYL AND ARALKYL, Y IS SELECTED FROM THE GROUP CONSISTING OF -HN-AC, PHTHALIMIDO AND-NH-R'',R'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN, ALKYL AND ARALKYL AND AC IS THE ACYL RADICAL OF AN ORGANIC CARBOXYLIC ACID OF 1 TO 18 CARBON ATOMS AND TO A NOVEL PROCESS FOR THE PREPARATION OF THE SAID COMPOUNDS.