Showing papers by "Torrey Pines Institute for Molecular Studies published in 2023"
TL;DR: In this paper , a root finding algorithm is proposed to screen and filter the discontinuity and breakdown points as well as imaginary roots of the determinant function associated with bending eigenfrequency and eigenbuckling matrices.
1 citations
TL;DR: In this article , the authors highlight challenges in early childhood care faced by academicians and highlight opportunities for change at the technological, cultural and policy levels at the societal, cultural, and policy level.
Abstract: As the inaugural entry in the new series Hidden Lives, this Viewpoint Article highlights challenges in early childhood care faced by academicians. Research centers must adapt to societal shifts in family structure, uncertainty around research funding, expanded job responsibilities and upheavals brought about by the pandemic. These problems represent opportunities for change at the technological, cultural and policy levels. It is crucial that we recognize those in need and help where we can.
12 May 2023
TL;DR: In this paper , a protocol for treating mice with the senolytic, Navitoclax, by oral gavage was proposed, which was shown to improve the survival of the mice.
Abstract: This protocol is for treating mice with the senolytic, Navitoclax, by oral gavage.
TL;DR: Zhang et al. as mentioned in this paper found that the PDE4B gene, other essential loci, and 274 genes' interaction with the environment could potentially cause anxiety, such as environmental changes, childhood trauma or physical abuse, and Mediterranean diet or the microbiome were strongly associated with disease development.
Abstract: There is still much debate about the etiology and remedies of anxiety disorders. Summarizing the current research results will facilitate a deeper understanding of anxiety disorders and uncover suitable treatments. Environmental changes, childhood trauma or physical abuse, and a Mediterranean diet or the microbiome were strongly associated with disease development. Also, the PDE4B gene, other essential loci, and 274 genes' interaction with the environment could potentially cause anxiety. Molecules such as the brain receptor GPR158, MicroRNA-137, and the interleukin-17a (IL-17a) showed increased anxiety behaviors. Psychological therapy, such as cognitive behavioral treatment, mindfulness-based cognitive therapy, and internet-delivered behavioral therapy, effectively reduces anxiety. Diazepam and clonazepam, secondary benzodiazepine treatments, showed shortcomings, for example, the former lack of cognitive recovery. Furthermore, SSRIs, including sertraline, fluoxetine, and paroxetine, and SNRIs like venlafaxine or duloxetine, had good efficacy and high tolerability. Animal-assisted intervention, cannabidiol, molecule therapeutics, and many novel approaches in different systems were also proved to be beneficial in decreasing anxiety symptoms. More evidence from studies and reviews is needed to support these findings.
TL;DR: In this paper , the authors highlight challenges in early childhood care faced by academicians and highlight opportunities for change at the technological, cultural and policy levels at the societal, cultural, and policy level.
Abstract: As the inaugural entry in the new series Hidden Lives, this Viewpoint Article highlights challenges in early childhood care faced by academicians. Research centers must adapt to societal shifts in family structure, uncertainty around research funding, expanded job responsibilities and upheavals brought about by the pandemic. These problems represent opportunities for change at the technological, cultural and policy levels. It is crucial that we recognize those in need and help where we can.