Showing papers in "Autoimmune Diseases in 2006"
TL;DR: The biological basis of disease at genetic, molecular, cellular, and epidemiologic levels is discussed and tissue-specific interventions to arrest or cure autoimmune disease are discussed.
Abstract: = Abstract Since publication of the Third Edition in 1998, the understanding of the immune mechanisms underlying autoimmunity and autoimmune disease has significantly deepened and broadened. This Fourth Edition incorporates new material and combines common themes underlying inductive and effector mechanisms and therapies that relate generally to the autoimmune disorders. It discusses the biological basis of disease at genetic, molecular, cellular, and epidemiologic levels. New to This Edition: * Tissue-specific interventions to arrest or cure autoimmune disease * Bone marrow eradication and replacement * Both basic science and clinical medicine is covered * Boxed points to emphasize key features of each chapter.
1,058 citations
[...]
TL;DR: This chapter focuses on sensorineural hearing loss (SNHL), and the association of IMIED with systemic autoimmune diseases provides evidence that autoimmunity can damage the inner ear, but it does not address organ-specific disease.
Abstract: Publisher Summary It is now evident that the inner ear is not an “immunologically privileged” site and may mount an immune response against both foreign and self-antigens. This chapter focuses on sensorineural hearing loss (SNHL). This has been described and termed in different ways: autoimmune SNHL, immunemediated inner ear disease (IMIED), idiopathic progressive bilateral SNHL, sudden SNHL, and idiopathic SNHL, bilateral immune-mediated Meniere's disease, autoimmune vestibulo-cochlear disorders, generating a great confusion in the identification of patients and in the evaluation of different studies. The association of IMIED with systemic autoimmune diseases provides evidence that autoimmunity can damage the inner ear, but it does not address organ-specific disease. Antibodies directed against different inner ear antigens have been identified in some patients. However, they are neither diagnostic nor correlate with disease state. In the future, the major goals for research in this field can be the identification of pathogenetically relevant autoantigens, development of a highly specific diagnostic test, and a better knowledge of the immunopathologic mechanisms in an organ as inaccessible as the inner ear.
3 citations