Showing papers in "Autophagy in 2003"

Signaling pathways in mammalian autophagy

Abstract: Macroautophagy is a major catabolic process conserved from yeast to human. The formation of autophagic vacuoles is stimulated by a variety of intracellular and extracellular stress situations including amino acid starvation, aggregation of misfolded proteins, and accumulation of damaged organelles. Several signaling pathways control the formation of autophagic vacuoles in mammalian cells. As some of these signaling pathways are engaged in either the control of protein synthesis or cell survival this suggests that macroautophagy is intimately associated with the execution of cell proliferation and cell death programs.