Showing papers in "Československá patologie in 1976"

Familial malignant melanoma

Abstract: Two families with a familiar occurrence of malignant melanoma have been described. In the first family malignant melanoma has been histologically verified in two generations. In the other family, malignant melanoma occurred in four generations, but it has been verified histologically in two of them only. In the remaining two generations there were positive anamnestic data.

[Malignant apudoma (argyrophilie carcinoma) of the uterine cervix in a 24-year-old woman in pregnancy].

Abstract: Report on a case of the malignant APUDOMAP (argyrophil cell carcinoma) of the uterine cervix in a 24-years old women. The tumor appeared during the third pregnancy and fatal generalization resulted cca three month after operative delivery and panhysterectomy. Histologically argyrophil cells were proved both in the primary localization and distant metastases (liver, lymph nodes, ovaries, brain, meninges, skeleton). In the electron microscope of the bioptic specimen specific granules and microfilaments were identified in some tumour cells supporting the diagnosis of a cancer of the APUD-series. Some general features of primary cervical APUDOMAS also outlined.

Functionally active tumor of the carotid body

Abstract: The clinical and biochemical pictures of a woman of 60 suffering from paroxysmal hypertension appeared to be clear evidence of a functionally active neoplasm of the sympathoadrenal tissue. A surgical operation ruled out the possibility of the tumour being localized adrenally so that the actual site of noradrenaline release was never found during the patient's lifetime. An autopsy discovered the presence of a carotid body tumor sized. 4.5X3X3 cm. The histological picture, electron microscopy as well as the positive isolation of noradrenalin all seemed to offer clear evidence of a functionally active tumour although the chromaffin reaction was negative. This is just additional evidence of the fact that the carotid body does belong among sympathetic paraganglia and that the chromaffin reaction is not sufficiently sensitive and reliable either for the determination of biogenic amines in the tissue or for a clear, unequivocal detection of functionally active tumours of the sympathetic.

[Kinetics and morphology of immune reaction cells in the spleen studied using the immuno-cyto-adherence reaction. V. Secondary response and its modification by whole-body irradiation at different intervals following administration of antigen].

Abstract: Observations were made of the course of secondary immunological response, using the immuno-cyto-adherence method under the influence of 450 r general body irradiation on murine spleen following secondary ram erythrocyte immunization. Irradiation was applied 24 hours, 72 hours and 6 days after an i.p. administration of antigen. Irradiation was immediately followed by an absolute as well as relative drop in RFC number and by an overall drop in splenic cell number. In case of irradiation applied prior to reaching the secondary reaction quantitative maximum, there was a development of the increment and another RFC quantitative maximum was reached between days 15--20 after irradiation. Small and medium size lymphocyte values were seen decreasing immediately after irradiation. Where irradiation took place prior to reaching the quantitative maximum of a normally proceeding anamnestic reaction, large lymphocytes constituting RFC were increasingly represented after a certain period of stagnation or even without it. Plasmatic series cells on irradiation tended to increase their total share to become a prominent cell element after delayed quantitative RFC maxima had been reached and to reach complete predominance towards the end of the period of time under observation. A relative increase in the proportion of macrophages was seen immediately after irradiation.

Mesothelial polyp of the epicardium

Abstract: In an autopsied male aged 31 who had been suffering from chronic bronchitis, a polyp anchored at the site of the crossing of the aorta with the pulmonary artery was found in the pericardial sac. Histologically, the polyp was classed as benign mesothelioma.

The course of healing of cutaneous wounds in young and old rats

Abstract: Healing of cutaneous wounds produced on the backs of young and old rats has been compared at ten various intervals between days 3 and 28. The only differences disclosed pertained to the exsudative and proliferative phases between days 3 and 5, which were found to develop more rapidly in young rats. The phase of the (predominantly afibrillar) connection of the wound stumps was reduced to less than 5 days. The exact nature of the "sticking" intercellular substance has not been clarified; most probably the substance represents nonfibrillar collagen. In the group of old rats neoformation of fibrillary neocollagen was somewhat more marked during days 7 to 9 than in yound rats, in whom a rather pronounced exsudative component was found during that period. No significant differences between the two groups were disclosed during the later stages of the experiment. Fibroblasts participated in collagen phagocytosis during the definitive reconstruction of the provisional, imperfectly oriented fibrillar connection of the wound edges.