Showing papers in "Chinese Journal of Diabetes in 2012"

Clinical care guidelines for cystic fibrosis-related diabetes

Abstract: Cystic fibrosis-related diabetes(CFRD)is the most common comorbidity in people with cystic fibrosisThese guidelines are the result of a joint effort between the Cystic Fibrosis Foundation,the American Diabetes Association,and the Pediatric Endocrine SocietyThe guidelines include recommendations for screening,diagnosis,and medical management of CFRDThis report focuses on aspects of the clinical care unique to CFRD

Association between the hypersensitive C-reactive protein and diabetes in the senile elders

Abstract: Objective To study the association between the hypersensitive C-reactive protein(hsC-RP) and diabetes in the senile elders.Methods The data including the basic conditions,life style,anthropometric measurements,plasma hsC-RP,TC,TG,and FPG,etc.in the 499 senile elders aged 90 years and over were collected and analyzed through questionnaire investigation,health examination,and laboratory assay.Results Logistic regression analysis showed that after adjustment of various confused factors,the hsC-RP was still in a significantly positive correlation with diabetes(P0.05),and the OR(95%CI) value was 1.94(1.08,3.48).Results of multivariate linear regression analysis also showed that the hsC-RP was significantly associated with the level of FPG(P0.01).The study also found that the TG was still an independent risk factor of diabetes in the senile elders(P0.05).Conclusion The hsC-RP is significantly and independently associated with diabetes in the senile elders.

Effect of licorice flavonoids on blood glucose,blood lipid and other biochemical indicators in type 2 diabetic rats

Abstract: Objective To study the effect of licorice flavonoids(LF) on fasting blood levels of glucose(FBG),lipids,insulin,adipokines and other biochemical indicators. Methods The type 2 diabetic rat model was replicated by feeding high-fat and high-sugar diet combined with low-dose streptozotocin(STZ) injection.The diabetic rats were divided into model group(DM),high-dose LF treatment group(HLF) and low-dose LF treatment group(LLF).Other 20 normal rats were divided into control group(Con) and control treatment group(CLF).Rats in different groups were administered LF(100mg or 300mg·kg-1·d-1) or solvent(propylene glycol) respectively.Five weeks later,the levels of fasting levels of glucose(FBG),triglycerides(TG),total cholesterol(TC),free fatty acids(FFA),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),total antioxidation capability(T-AOC),insulin(Ins),tumor necrosis factor alpha(TNF-α) and leptin were examined.Insulin sensitivity index(ISI),liver index,kidney index and the relative weight of abdominal adipose tissue were calculated. Results The high-dose LF(300mg·kg-1·d-1) treatment significantly decreased the levels of FBG,TG,TC,LDL-C,FFA,T-AOC,TNF-α,leptin,liver index and kidney index,and increased the levels of T-AOC,ISI and the relative weight of abdominal adipose tissue.Compared with high-dose treatment,low dose of LF was less effective. Conclusion LF significantly decreases the blood glucose level,improves the lipid metabolic disorders and ameliorates insulin resistance in type 2 diabetic rats.

Associations between the serum cholinesterase and complications of type 2 diabetes

Abstract: Objective To study the associations between the serum cholinesterase(CHE)and complications of type 2 diabetes. Methods 201 cases of hospitalized patients with type 2 diabetes from March 2008 to February 2009 were enrolled as study subjects.Fasting blood were drawn for detecting cholinesterase,blood lipids,glycated hemoglobin and other indicators.Results Serum CHE level in fatty-liver group and macroangiopathy group was obviously higher than in non-fatty-liver group and non-macroangiopathy group(P0.0001,P0.05).Multiple stepwise regression analysis showed that body mass index,triglycerides and apolipoprotein B were the main factors affecting serum CHE level(P0.05).There was no significant difference in serum cholinesterase level between patients with or without diabetic neuropathy and diabetic nephropathy(P0.05). Conclusions Serum CHE level is relevant with diabetic macroangiopathy.

Urinary C-peptide creatinine ratio(UCPCR) is a practical outpatient tool for identifying HNF1A/HNF4A MODY from long duration type 1 diabetes

Abstract: Besser REJ,Knight BA,Shepherd MH,et al compared stimulated UCPCR in adults with HNF1A/4A MODY,type 1diabetes,and type 2diabetes in"Urinary C-peptide creatinine ratio(UCPCR)is a practical outpatient tool for identifying HNF1A/HNF4A MODY from long duration type 1 diabetes"(Diabetes Care,2011,34:286-291),and concluded UCPCR was a noninvasive outpatient tool that can be used to discriminate HNF1A and HNF4A MODY from long-duration type 1 diabetes.To differentiate MODY from type 1diabetes of5years’duration,UCPCR could be used to determine whether genetic testing is indicated.The essential parts were tanslated in the following article.

Epidemiological survey of prevalence of metabolic syndrome and its risk factors in medical professionals

Abstract: Objective To identify the prevalence of metabolic syndrome(MS) and its risk factors in medical pnofessionals.Methods The 1996 medical workers were recruited and divided into groups according to age and the nature of their work respectively.The height,body weight,waist circumference,and blood pressure were measured in these individuals.Meanwhile,fasting blood glucose,serum total cholesterol,triglyceride,high density lipoprotein(HDL-C) were also tested.Results(1) The prevalence of MS was 9.17%(according to CDS,2004) and 11.16%(according to Chinese guidelines on prevention and treatment of dyslipidemia in adults,2007) respectively.(2) The prevalence of MS increased along with age(P0.01),and it was higher in male than in female(P0.01).(3) The risk factors of MS included abdominal obesity,overweight,hypercholesterolemia,low HDL-C,hyperglycemia,hypertension and non-alcoholic fatty liver.The prevalence of hypertension in medical workers was higher than in general population.(4) The prevalence of MS was associated with the nature of work.Conclusions The prevalence of MS in medical pnofessionals is similar to that in general population,but the occurrence of hypertension in medical workers is higher than in general population.

Effect of combined therapy with alfacacidol and telmisartan on diabetic nephropathy in early stage

Abstract: Objective To investigate the effect of combined therapy with alfacalcidol and telmisartan on the diabetic nephropathy in early stage.Methods The 60 diabetic nephropathy patients in our hospital were enrolled.They were randomly divided into three groups.Group A was treated with alfacalcidol 0.25 μg per day,group B was treated with telmisartan 20~40 mg per day,and group C was treated with alfacalcidol 0.25 μg and telmisartan 20~40 mg per day.The blood pressure of all the patients was controlled below 125/75 mmHg.The fasting blood glucose(FBG),HbA1c,BP,24 h urinary protein,urea nitrogen(BUN),serum creatinine(Scr),calcium(Ca2+),and potassium(K+) were measured before and 12 weeks after experiment.Results The 24 h urine protein in all the groups was decreased(P0.05) after 12 weeks.Compared with group A and B,the 24 h urine protein in group C was significantly decreased(P0.01).There were no significant differences in other indices(P0.05).There were no obvious adverse effects during the treatment in all groups.Conclusion Both alfacalcidol and telmisartan can reduce the urine protein excretion in diabetic nephropathy patients.And the combination therapy has additive efficacy.

The effects of blood glucose control on levels of monocyte chemoattractant protein-1(MCP-1)activity in peripheral blood of patients with hyperglycemic crisis

Abstract: Objective To investigate the effects of blood glucose control on levels of monocyte chemoattractant protein-1(MCP-1)activity in peripheral blood of patients with hyperglycemic crisis.Methods A total of 84 patients with diabetic ketoacidosis(DKA)and nonketotic hyperglycemia(NKH) patients were selected.MCP-1 levels were assayed at 72 hours after glucose control.Serum MCP-1 was assayed by ELISA.Results The serum MCP-1 before treatment were higher in patients with hyperglycemia crisis than in normal control.The relationship analysis showed that MCP-1 levels were positivily related to fasting blood glucose(FBG),2-h postprandial glucose,and HOMA-IR(r=0.506,r=0.854,r=0.283,P0.01).Conclusion The levels of serum MCP-1 are decreased at 72 hours after blood glucose control.The improvement of blood glucose control contributes to the improvement of inflammatory status.

The investigation and analysis of the control state of type 2 diabetes in Beijing

Abstract: Objective To investigate the state of T2DM control in tertiary first-class hospitals in Beijing.Methods 1151 patients with T2DM were recruited as the study subjects in 6 tertiary first-class hospitals in Beijing.The message was collected to evaluate the state of T2DM control via interview,medical records and electronic laboratory enquiry system.The evaluation criteria were defined based on 2007 China Guideline for T2DM.Results The age was(60.8±9.2) years old,the disease duration was 7.3 years,the BMI was(24.6±3.3)kg/m2,and the HbA1c level was(7.15±1.50)%.The target arrival rates of HbA1c,BP,TG,HDL-C,LDL-C,and TC were 37.8%,65.6%,48.8%,59.2%,34.0%,and 42.0%,respectively.Conclusions The metabolic control of T2DM in tertiary first-class hospital is better in Beijing than in the domestic and abroad,but there is a wide gap as compared with 2007 China Guideline for T2DM.

A survey on medical personnel's knowledge of nutrition management of diabetes mellitus

Abstract: Objective To understand the medical personnel's attitude and knowledge of diabetes nutrition management.Methods A questionnaire survey was conducted among 944 clinical medical personnel of 27 cities in China from July to August 2010.Results The attitude of most medical personnel to medical nutritional treatment was positive,while their knowledge of nutrition management of diabetes mellitus was on the low level.Conclusion The medical personnel's knowledge level of nutrition management for diabetes mellitus is relatively low.The training on medical nutritional treatment for diabetes mellitus should be strengthened.

Relationship of serum 8-OHdG and VEGF with diabetic nephropathy in diabetics

Abstract: Objective To investigate the relationship of serum 8-hydroxy-guanine(8-OHdG) and vascular endothelial growth factor(VEGF) with diabetic nephropathy(DN).Methods The levels of serum 8-OHdG,VEGF,and 24 h albuminuria were measured by ELISA in 71 DN patients,73 T2DM patients,and 47 healthy people.The results were compared to observe the difference among them.Results The levels of serum 8-OhdG and VEGF in the diabetic nephropathy patients were significantly higher than in the T2DM patients(P0.01).The levels of serum 8-OhdG and VEGF in the T2DM patients were higher than in the normal control group(P0.05).The levels of serum 8-OhdG and VEGF in the macroalbuminuria group were significantly higher than in the microalbuminuria group(P0.05).The levels of serum 8-OhdG and VEGF in the HbA1c10% group were significantly higher than in the HbA1c9% group(P0.05).Conclusion The diabetic nephropathy is related with serum 8-OHdG and VEGF.Oxidative stress and VEGF play important roles in the pathogenesis of diabetic nephropathy.

Meta-analysis on the HLA-DR gene polymorphisms of T1DM in Chinese populations

Abstract: Objective To evaluate the relationship between the allele polymorphism of HLA-DR and T1DM in the Chinese populations.Methods The odds ratios(OR) of HLA-DR allele distributions in T1DM patients were analyzed against healthy controls.All the relevant studies in Wanfang Data,CNKI,Chinese Science and Technology Periodical Database VIP Information,and Pubmed were identified,and poorly qualified studies were excluded.The meta-analysis software REVMAN 5.0 was applied for summarizing OR of relevant alleles in all the studies.The publication bias was also evaluated.Results DR3,DR4,DRB1*0301,and DRB1*0405 were the susceptible alleles(all P0.05) in the Chinese populations,their merger OR were 4.42,2.18,6.04,and 3.21 respectively.DR2,DR6,DR15,and DRB1*1101 were the protective alleles(P0.05),and their merger OR were 0.31,0.50,0.51,and 0.35 respectively.DR3/DR4 and DR3/DR9 were also the susceptible genotypes(P0.05),and their merger OR were 25.36 and 5.21 respectively.Conclusion In the Chinese populations,some HLA-DR alleles relevant to T1DM are not totally the same as in the reports on non-Chinese populations.Susceptible alleles in China such as DR3,DR4,DRB1*0301,DRB1*0405,DR3/DR4,and DR3/DR9 match those of the non-Chinese populations,while the protective DR2 also agrees with the non-Chinese ones.And other alleles are quite different.

Effect of reducing serum uric acids on insulin resistance and islet β cell functions in patients with hyperuricemia

Abstract: Objective To observe whether the treatment of reducing serum uric acids(UA) for hyperuricemia(HUA) could improve the insulin resistance(IR) and islet β cell functions of the patients.Methods Sixty HUA patients without clinical symptoms were randomized into treatment and control groups.The treatment group had low purine diet and took oral allopurinol,while the control group received no treatment.The indices of body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),triglycerides(TG),total cholesterol(TC),low density lipoprotein cholesterol(LDL-C),fasting plasma glucose(FPG),fasting insulin(FIns),insulin resistance(HOMA-IR),and islet β cell functions(by homeostasis model assessment,HOMA-β) were observed.Results There was no significant difference in the levels of UA,BMI,SBP,DBP,TG,TC,LDL-C,FPG,FIns,HOMA-IR,and HOMA-β between two groups before treatment(P all0.05).The UA level after treatment was significantly lower than before treatment in the treatment group(P0.01).The difference in the UA level before and after treatment was not statistically significant in the control group(P0.05).Comparing with before treatment,the levels of BMI,SBP,DBP,TG,TC,LDL,FPG,FIns,HOMA-IR,and HOMA-β after treatment were not significantly different in both groups(P all0.05).Conclusion The low purine diet and oral allopurinol for HUA control is not helpful for improving IR and islet β cell functions of the patients.

The study of the role of IRS1 and its serine phosphorylation activity in pathogenesis of insulin resistance

Abstract: Objective To investigate the effects of insulin receptor substrate 1(IRS1) and activity of IRS1 serine phosphorylation on the development of insulin resistant. Methods 20 male C57BL/6 mice were divided into normal diet group(NC) and high fat diet group(HF) and all mice showed insulin resistance.The mice in HF were fed with high fat diet for 16 weeks.Serum insulin concentration was also evaluated by ELISA.RT-PCR,Western blot and immunofluorescence were performed to detect TSC2 and IRS1 mRNA and protein expression in skeletal muscle. Results As compared with NC group,HF group showed that fasting insulin value was increased(P0.01),OGTT was damaged,mRNA and protein expressions of TSC2 of skeletal muscle of mice were decreased(P0.05),and the expression of pIRS1Ser307 and pIRS1Ser636/639 was increased(P0.01).Conclusions High-fat diet possibly produces IR by inhibiting TSC2 mRNA and protein expression,and by increasing IRS1Ser307 and IRS1Ser636/639 phosphorylation levels in mice skeletal muscle.