Journal•
Default Digital Object Group
About: Default Digital Object Group is an academic journal. The journal publishes majorly in the area(s): Computer science & Medicine. Over the lifetime, 249 publications have been published receiving 1 citations.
Topics: Computer science, Medicine, Internal medicine, Chemistry, Biology
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TL;DR: Neoantigens are encoded by mutations that are present only in tumors and not in normal tissues as discussed by the authors , and they are present in any patient who is afflicted by cancer.
Abstract: Neoantigens are encoded by mutations that are present only in tumors and not in normal tissues. Because of the adaptive immune system’s ability to discriminate between “nonself” and “self, ” coupled with the vast diversity of T-cell receptors, neoantigen-specific T cells are universally present in any patient who is afflicted by cancer.
1 citations
TL;DR: In this paper , Amplification of the HER2 gene (ERBB2) is the latest targetable molecular subset in patients with metastatic colorectal cancer, such as BRAF V600E mutations and deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H).
Abstract: Despite advances in treatment over the last 2 decades, metastatic colorectal cancer (mCRC) remains a leading cause of cancer-related mortality. Recent therapeutic advances have improved the outcomes for patients with certain molecular subtypes of mCRC, such as BRAF V600E mutations and deficient mismatch repair (dMMR)/high microsatellite instability (MSI-H). Amplification of the HER2 gene (ERBB2) is the latest targetable molecular subset in patients with mCRC.
1 citations
TL;DR: In men with metastatic hormone-sensitive prostate cancer (mHSPC), the addition of enzalutamide to testosterone suppression continues to provide a significant improvement in overall survival after more than 5 years, according to an update from the phase 3 ENZAMET trial as discussed by the authors .
Abstract: In men with metastatic hormone-sensitive prostate cancer (mHSPC), the addition of enzalutamide to testosterone suppression continues to provide a significant improvement in overall survival (OS) after more than 5 years, according to an update from the phase 3 ENZAMET trial presented by Ian D. Davis, MBBS, PhD, FRACP, FAChPM, of Monash University and Eastern Health, in Australia, during the 2022 ASCO Annual Meeting LBA5004).
1 citations
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TL;DR: In this paper , the authors investigate the motion of groups of intruders in a two-dimensional granular system by using discrete numerical simulations and show that the cooperative dynamics is the result of contact chains linking the intruders and compaction and expansion of the granular medium in front and behind, respectively, each intruder.
Abstract: We investigate the motion of groups of intruders in a two-dimensional granular system by using discrete numerical simulations. By imposing either a constant velocity or a thrusting force on larger disks (intruders) that move within smaller ones (grains), we obtained instantaneous positions and components of forces for each intruder and grain. We found that (i) intruders cooperate even when at relatively large distances from each other; (ii) the cooperative dynamics is the result of contact chains linking the intruders as well as compaction and expansion of the granular medium in front and behind, respectively, each intruder; (iii) the collaborative behavior depends on the initial arrangement of intruders; and (iv) for some initial arrangements, the same spatial configuration is eventually reached. Finally, we show the existence of an optimal distance for minimum drag for a given set of intruders, which can prove useful for devices stirring the ground or other granular surfaces.