Showing papers in "Dermatology in 1971"
TL;DR: Investigation of the skin shows an irregular epidermic hypochromy without pigment loss in the upper dermis, decrease and morphological immaturity of melanocytes, disturbance of keratinization with growth of large clear cells and malformation of skin appendages.
Abstract: Four new cases of Iτo’s Incontinentia pigmenti achromians developing in 1 family, the mother and her 3 daughters, are reported by the authors Histopathological investigations of the skin show an irregular epidermic hypochromy without pigment loss in the upper dermis, decrease and morphological immaturity of melanocytes, disturbance of keratinization with growth of large clear cells and malformation of skin appendages The pathological correlations of I P achromians (Iτo) and histopathological pecularities are similar to those of I P (Bloch-Sulzberger)
66 citations
TL;DR: The incidence of allergic contact sensitivity in a group of eczematous patients was recorded for substances which can be used as constituents of vehicles in topical medicaments or as active drugs and the highest non-irritant concentration of a number of substances was ascertained.
Abstract: Medicament-induced skin diseases accounted for 6.8% of 14,400 cases of skin diseases observed between 1967 and 1970. In only 0.4% of the patients was a non-allergic medicament contact dermatitis present. The remaining 6.4% of the patients had an allergic medicament eruption; in 5% this was due to an allergic contact dermatitis, in the remaining 1.4% immediate-type allergic reactions were involved. The incidence of allergic contact sensitivity in a group of eczematous patients was recorded for substances which can be used as constituents of vehicles in topical medicaments or as active drugs1. This included only 1 base, wool alcohol, but several ‘additives’. By patch-testing 50 healthy volunteers the highest non-irritant concentration of a number of substances, which can be used as constituents of topical medicaments, was ascertained. These concentrations are compared with the concentrations commonly in use in ready-made preparations available in Italy.
57 citations
TL;DR: A case of multiple sebaceous tumours and kerato acanthomata of the skin in a man who in a period of 21 years was also treated twice for a carcinoma of the colon and once for a cancer of the stomach is presented.
Abstract: The authors present a case of multiple sebaceous tumours and kerato acanthomata of the skin in a man who in a period of 21 years was also treated twice for a carcinoma of the colon and once for a carcinoma of the stomach. In the literature only two comparable cases have been found. It is suggested that these three cases represent examples of a rare syndrome.
53 citations
TL;DR: The intimate topographic relationship between the epithelial and mesenchymal components suggests that the lesion arises as a consequence of abnormal adnexogenesis involving biochemical evocators of these respective components.
Abstract: A skin lesion consisting of increased numbers of eccrine sweat ducts associated with enveloping angiomatous vascular channels is presented Although a small number of similar lesions have been described, the present case is unique in that the regional pilar structures were also involved by the periadnexal vascular proliferation The intimate topographic relationship between the epithelial and mesenchymal components suggests that the lesion arises as a consequence of abnormal adnexogenesis involving biochemical evocators of these respective components
52 citations
TL;DR: A clinico-pathologic study is made of 12 cases with tumor of follicular infundibulum, which appears as a slightly elevated keratotic lesion and is characterized histologically by proliferation of follicle sheath epithelium in the form of a thin subepidermal plate.
Abstract: A clinico-pathologic study is made of 12 cases with tumor of follicular infundibulum. This tumor appears as a slightly elevated keratotic lesion and is characterized histologically by proliferation of follicular sheath epithelium in the form of a thin subepidermal plate.
45 citations
TL;DR: The follicular-keratogenic properties of several fatty acids were investigated by application in the external ear canal of the rabbit by inducing marked and marked responses to Laurinic acid and oleic acid.
Abstract: The follicular-keratogenic properties of several fatty acids were investigated by application in the external ear canal of the rabbit. Laurinic acid and oleic acid induced marked, and caprinic acid mo
39 citations
TL;DR: Clear cell acanthoma is a benign neoplasm of keratinocytes usually occurring as a single lesion and not found with an underlying skin disorder and a patient is reported with generalized lamellar ichthyos.
Abstract: Clear cell acanthoma is a benign neoplasm of keratinocytes usually occurring as a single lesion and not found with an underlying skin disorder. A patient is reported with generalized lamellar ichthyos
38 citations
TL;DR: A case of hypersensitivity to chlorhexidine is described, and Absorption maxima are reported and the possibility of photoallergy is discussed.
Abstract: A case of hypersensitivity to chlorhexidine is described. When test areas were irradiated in different ways, stronger test reactions were obtained. Wood’s light produced the most distinct intensification of the effect; the patient reacted to 0.0156%, compared with 0.125% chlorhexidine solution without irradiation. Absorption maxima are reported and the possibility of photoallergy is discussed.
34 citations
TL;DR: Antipsoriatic response to topical administration of 0.1- and 0.3-percent retinoic acid (vitamin A acid) has been determined in a single blind study as compared with placebo and crude coal tar.
Abstract: Antipsoriatic response to topical administration of 01- and 03-percent retinoic acid (vitamin A acid) has been determined in a single blind study as compared with placebo and crude coal tar Forty consecutive patients with chronic psoriasis were included in the study Both concentrations of retinoic acid and crude coal tar were significantly more effective than placebo following 2 weeks of application, and 03-percent retinoic acid was more effective than crude coal tar Irritation in the form of erythema was noted with the 03-percent concentration of retinoic acid
26 citations
Journal Article•
25 citations
TL;DR: A female patient contracted a contact dermatitis which was caused by a baby body lotion, apparently her baby was not sensitive to this lotion.
Abstract: A female patient contracted a contact dermatitis which was caused by a baby body lotion. Apparently her baby was not sensitive to this lotion. The causative agent was chloracetamide which was used as
TL;DR: The homogenate of the epidermis was found to contain immunogenic substances and one of its subcellular fractions could elicit intense contact hypersensitivity although it contained less amounts of haptenic groups than other fractions.
Abstract: To elucidate the sensitization mechanism of allergic contact dermatitis isolation of carrier substances from DNCB-treated epidermis was attempted. The homogenate of the epidermis was found to contain immunogenic substances. One of its subcellular fractions could elicit intense contact hypersensitivity although it contained less amounts of haptenic groups than other fractions. Electron microscopy revealed it to be the microsomal fraction of epidermal cells. Treatment of the fraction with deoxycholic acid caused slight reduction of its immunizing ability.
TL;DR: It is postulated that the relatively high incidence of chromate sensitivity among women with housewives’ eczema living in this region is related to the photosensitizing properties of chromates.
Abstract: This study showed that 229 (91.6%) of 250 patients with housewives’ eczema tested positive or strongly positive to a patch test with potassium dichromate. The possible relationship between this finding and the use of detergents was investigated by making a quantitative determination of the chromate content of 14 detergents widely used in Israel. A method found by the author to give very reliable results was used for this purpose (full details are presented). All the detergents tested were found to contain chromates in varying amounts, with the largest amounts present in bleaching solutions. It is postulated that the relatively high incidence of chromate sensitivity among women with housewives’ eczema living in this region is related to the photosensitizing properties of chromates.
TL;DR: A patient had the sudden onset of multiple deep subcutaneous abscesses from which Trichophyton rubrum was isolated, and the clinical history and physical findings of the patient suggest it is likely that the patient had an abscess of the Tournaisian type.
Abstract: A patient had the sudden onset of multiple deep subcutaneous abscesses from which Trichophyton rubrum was isolated. The clinical history and physical findings of the patient suggest
TL;DR: A case of inoculation leprosy resulting after 7 years of tatooing in a female aged 25 years is described and an inoculation by lepra ba is illustrated.
Abstract: A case of inoculation leprosy resulting after 7 years of tatooing in a female aged 25 years is described. This conforms to high resistant tuberculoid leprosy and illustrates an inoculation by lepra ba
TL;DR: A genealogical study of lipoid proteinosis indicates that most, if not all, South African patients are probably descendants of a brother and sister, Jacob and Elsje Cloete, who settled in the Cape early in the latter half of the 17th century.
Abstract: A genealogical study of lipoid proteinosis indicates that most, if not all, South African patients are probably descendants of a brother and sister, Jacob and Elsje Cloete, who settled in the Cape early in the latter half of the 17th century. It is suggested that a similar genealogical study be undertaken of patients in other countries to see whether more of them could be traced to the same family.
TL;DR: Patch testing with the ring and sodium aurothiosulfate of very low concentration found contact dermatitis on a 28-aged female patient after wearing a golden ring during one and a half year.
Abstract: Contact dermatitis due to gold is a rarity. We saw it on a 28-aged female patient after wearing a golden ring during one and a half year. Patch testing with the ring and sodium aurothiosulfate of very
TL;DR: The clinical and histological findings of 2 patients with acute febrile neutrophilic dermatosis are described and Associated clinical features suggest that a hypersensitivity reaction is responsible for this illness.
Abstract: The clinical and histological findings of 2 patients with acute febrile neutrophilic dermatosis are described. Associated clinical features in 1 case suggest that a hypersensitivity reaction is responsible for this illness.
TL;DR: Two patients with pityriasis rubra pilaris (PRP) in childhood were observed and the affection was characterised by an acute onset and relatively short evolution.
Abstract: Two patients with pityriasis rubra pilaris (PRP) in childhood were observed. The affection was characterised by an acute onset and relatively short evolution. It was not noted that the disease was fam
TL;DR: From spectral reflectance curves of 631 individuals of three ethnic groups (colour-coded as white, brown and black) the lightest, darkest and several intermediate individuals were selected for ref.
Abstract: (1) From spectral reflectance curves of 631 individuals of three ethnic groups (colour-coded as white, brown and black) the lightest, darkest and several intermediate individuals were selected for ref
TL;DR: Reactive perforating collagenosis is a recently-recognized entity, in which a series of epidermal changes lead to elimination of altered collagen bundles through the transepidermal route.
Abstract: Reactive perforating collagenosis is a recently-recognized entity, in which a series of epidermal changes lead to elimination of altered collagen bundles through the transepidermal route. Clinically t
TL;DR: The specific resistances of various substances to the passage of water were measured and the reliability of the results was found to be reliable.
Abstract: The specific resistances (SR) of various substances (a.o. vaseline, wool-fat, emulsions, paraffins, vegetable oils, simple esters) to the passage of water were measured. The reliability of the experim
TL;DR: A case of the so-called blue rubber-bleb nevus, which appeared in old age, with an anorectal bleeding is presented, and it is proposed to call this entity ‘multiple skin and gastro-intestinal haemangiomata’ because the name describes the main features of this syndrome.
Abstract: A case of the so-called blue rubber-bleb nevus, which appeared in old age, with an anorectal bleeding is presented. Thrombocytopenia and hypercalcemia present in the case, are discussed and the pertinent literature is reviewed. The curious coincidence of 2 cystic squamous cell carcinoma in the groin is discussed, in view of the reported coincidence of other tumours. We propose to call this entity ‘multiple skin and gastro-intestinal haemangiomata’. This because the name describes the main features of this syndrome; moreover, it would call attention to the possibility of gastro-intestinal haemangiomata in such cases.
TL;DR: Antibodies to T. schoenleinii were found in sera of favus patients by charcoal agglutination and immunodiffusion analyses.
Abstract: Antibodies to T. schoenleinii were found in sera of favus patients by charcoal agglutination and immunodiffusion analyses.
TL;DR: The pigmented spots on 2 patients of the Caucasian race suffering from Albright's syndrome have been studied by optical and electron microscopy and are characterized by melanin hyperpigmentat.
Abstract: The pigmented spots on 2 patients of the Caucasian race suffering from Albright’s syndrome have been studied by optical and electron microscopy. These spots are characterized by melanin hyperpigmentat
TL;DR: The histological details of a pale cell acanthoma (Degos) is presented and the pale cells are probable differentiations of the spinal layer cells, which are given in the norm such as in the oral mucosa.
Abstract: The histological details of a pale cell acanthoma (Degos) is presented. The described lesion showed marked sweat duct hyperplasia, atopical placed sebaceous glands and small epithelial formations with differentiation to sebaceous gland cells. Of this the pale cell acanthoma (Degos) is interpreted as a hamartomal tumor. The pale cells are probable differentiations of the spinal layer cells, which are given in the norm such as in the oral mucosa.
TL;DR: A survey is given of a number of investigations concerning the question of identity or non-identity of housedust and D. pteronyssinus mite allergen.
Abstract: A survey is given of a number of investigations concerning the question of identity or non-identity of housedust and D. pteronyssinus mite allergen. Skin tests sho
Journal Article•
TL;DR: Two cases with extensive verrucous lesions, mainly on the limbs, appearing during adult life are described, and possible associations with other hyperkeratotic conditions are explored.
Abstract: Two cases with extensive verrucous lesions, mainly on the limbs, appearing during adult life are described. Possible associations with other hyperkeratotic conditions are explored and the difficulties
TL;DR: The clinicopathological findings in three sporadic cases of late mutilating bejel of the mid-face and mouth have been described in two bedouin men and a bedou in woman from the Great Arabian Peninsula on the outskirts of Kuwait.
Abstract: The clinicopathological findings in three sporadic cases of late mutilating bejel of the mid-face and mouth have been described in two bedouin men and a bedouin woman from the Great Arabian Peninsula on the outskirts of Kuwait. The epidemiology, differential diagnosis and the relevant literature of bejel or non-venereal endemic syphilis have also been discussed.