Showing papers in "Indian Journal of Pharmaceutical Sciences in 1983"

Studies on Centchroman, a new antifertility compound.

Abstract: This paper reports the results of laboratory research on the chemical properties analytic specifications assay method and stability of centchroman--34-trans-22-Dimethyl-3-phenyl-4(p-beta-pyrrolidinoethoxy)-7-methoxychromanhydrochloride. This compound has been reported to possess potent antifertility activity anti-inflammatory activity and to induce ovulation in anovulatory women. The crystalline compound is almost insoluble in water and has a pKa value of 2.1. Ultraviolet spectrophometric and colorimetric tests produced 98-102% recovery of added centchroman. Further studies indicated that the compound remains stable under storage conditions for 3 1/2 years with no marked change in color and general appearance. Finally no change in general appearance purity ultraviolet pattern and assay were observed after the compound was heated at 105 degrees for 6 hours. Although the above tests involved the pure compound additional tests with the tablet form revealed 100% stability even after 3 years of storage again with no change in color or general appearance.