Showing papers in "Journal of Investigative Dermatology in 1964"

TL;DR: Some of the factors which determine the rate of penetration of a neutral compound into and through normal skin are: (a) concentration of the penetrant in the presenting vehicle; (6) size of the penetrating molecule; (c) solubility characteristics; (d) solvent characteristics of the vehicle, and (e) temperature.

TL;DR: In this article, it was shown that partial genetic blocks may cause abnormalities of porphyrin metabolism in patients whose skin responds to moderate amounts of ultraviolet energy with formation of the characteristic lesions of polymorphic photodermatitis, i.e., macules, papules, plaques, wheals, vesicles, and eczematous dermatitis.

TL;DR: The anatomy of the horny layer is usually spoiled beyond recognition by tissue processing, whereas in fact it is a coherent, plastic membrane which serves as the ''barrier against the inward and outward movement of all substances including water''.

TL;DR: It is felt it would be appropriate to accumulate figures concerning the number of mast cells in relation to age, race, and sex, and on their distribution according to regions of the body, in an attempt to find a standard by which variations from the normal may be detected and which may serve as an aid in the study of skin diseases.

TL;DR: The role of the unsaturated iron-binding capacity of serum in its growth inhibitory action on Candida albicans is dealt with.

TL;DR: It is generally recognized that pigment spread is one of the most provocative and potentially important phenomena in the field of mammalian skin pigmentation and its color transformation is entirely restricted to the superficial epidermis, so that hair color always remains unaffected.

TL;DR: An investigation of the relationship of sebaceous gland activity to acne in a study of males with acne in whom quantitative gravimetric determinations of sebum production were performed and compared to normal control subjects and the sebum of these individuals was examined for a possible qualitative abnormality.

TL;DR: Although wound healing has been studied for more than three quarters of a century little progress was made in understanding the mechanism by which the wound surface becomes covered, recent studies of Lash in amphibia indicated that the epithelial cells move in a wave-like fashion over the wound.

TL;DR: A number of investigators have established that long term exposure to sunlight results in dermal elastosis in the exposed skin, but experiments using artificial ultraviolet sources has not been reported.

TL;DR: Understanding of the biochemical changes occurring in the epidermal cell following irradiation remains limited, but there is increasing interest in studying mammalian tissues.

TL;DR: The normalcy or abnormalcy of hair and its patterns of growth can only be appreciated by taking into account as many of the biologic criteria of hair as possible, e.g. total population of hair in a given body region, density of population, rate of growth, state of the growth cycle, thickness of the hair shaft, maximum length of hair shaft.

TL;DR: The present paper deals with the effect of thiabendazole in vitro on various pathogenic and saprophytic fungi, including cultures which are known to produce mycotoxins.

TL;DR: The suggestion that in epidermis of freckled individuals there may be two types of melanocyte with inherently different capacities for melanogenesis, each of which is a member of a distinct and “true-breeding” somatic cell lineage is suggested.

TL;DR: In this paper, the behavior of the desmosomes and the tonofilaments in pemphigus foliaceus was studied and found to serve an important function in the process of keratinization.

TL;DR: The eccrine sweat glands are innervated by cholinergic postganglionic fibers of the sympathetic system and both systemic and locally administered sympatholytics, or anticholinergics, have been shown to inhibit eccrine sweating.

TL;DR: The results of dermatological research and therapy with topically applied medications are influenced by several factors among which the total amount applied and the specific area of application are important ones, but these factors are often neglected or ignored.

TL;DR: This investigation has as its aim to establish the normal values of some of the characteristics of the hair of the prepubertal scalp: population density of hairs in given areas, caliber or thickness and its variation, daily growth rates, and frequency of the different stages of thehair cycle.

TL;DR: The demonstration of acid phosphatase in a variety of tissues has taken on new significance following the development of the lysosome concept and has been used as a “marker” for these structures in histochemical studies.

TL;DR: Baetjer, Damron and Budacz as mentioned in this paper investigated the interactions of both tri-and hexavalent chromium with lung tissue, and found that only trivalent was bound to the tissue.

TL;DR: The corn parison of the metal compounds with one another is considered as of primary importance, and for this reason great significance has been attached to the application of a uniform experimental method.

TL;DR: The present experiment was designed to study the influ-ence of alpha M.S.H. on the melanocytes and melanin in the epidermis of the male and female guinea pig.

TL;DR: In the recent period, largely through the efforts of Van Scott et al. the hair plucking technic has been formalized and brought to prominence in the study of human hair.

TL;DR: Investigations with the light microscope have shown that the base of the hair follicle consists of undifferentiated, pluri-potential, cuboidal matrix-cells which give rise to four different cell types: those of the medulla, the cortex, the cuticle and the inner root sheath.

TL;DR: Once seen, steatocystoma multiplex is there- after instantly recognized; however, the search- light of histopathology has not been truly focused on the darkest recesses of these curious cysts, methods Nineteen cysts from five patients have been semi-serially sectioned and stained with hematoxylin and eosin, periodic-Schifi, toluidine.