Showing papers in "Medical and Clinical Chemistry in 2016"
TL;DR: An analysis of published materials on the role of nitric oxide and its metabolites in the regulation of the stomach functional activity and the possibility of drug correction of infringements is presented.
Abstract: The article presents an analysis of published materials on the role of nitric oxide (NO) and its metabolites in the regulation of the stomach functional activity. The current information on the structure of nitric oxide, its formation and metabolism, meaning in the digestive system was analyzed. The analysis of published data on NO metabolism of the digestive system and stomach in particular was made. The role of nitreropic system secretory activity of the stomach and its motility. Separately there was analyzed data of current research on the role of nitric oxide and its metabolites in the pathology of the stomach and the possibility of drug correction of infringements.
3 citations
TL;DR: Physiological properties provide CO2 diverse local and resorptive effects, due to this carboxytherapy has become an effective and safe method of treatment in many areas of medicine.
Abstract: CO2 due to the optimal mechanism of maintaining of its reserve is a universal condition for the existence of the body. A physiological concentration of CO2 in the cells is an absolutely necessary condition for normal course of biochemical processes. CO2 is a natural regulator of respiration, blood circulation, metabolism, electrolyte balance, acid-base balance, the excitability of nerve cells, smooth muscle tone. Physiological properties provide CO2 diverse local and resorptive effects, due to this carboxytherapy has become an effective and safe method of treatment in many areas of medicine.
3 citations
TL;DR: In this article, the authors presented the results of the research of medical physical and chemical qualities of domestic remedy "Decamethoxin®", produced by Pilot Manufacturing of Institute of Organic Chemistry of National Academy of Sciences of Ukraine.
Abstract: In the article there were presented the results of the research of medical physical and chemical qualities of domestic remedy “Decamethoxin®” (Decamethoxinum®), produced by Pilot Manufacturing of Institute of Organic Chemistry of National Academy of Sciences of Ukraine. It was found, that “Decamethoxin®” (DC M) remedy complies physical and chemical requirements (color, transmittance, specific optical rotation, entertainable amount of impurities, sulfate ash, heavy metals, residual amounts of organic substances, the loss of the weight no more than 4.5 %, while desiccation), established for patented exemplar of decamethoxin®. Kinetics of DCM® elution into water medium from medical materials was proved. There was found, that elution of DCM® proceeded long (for 15 days), it was like programmed controlled process, occurring due to diffusion and kinetic mechanisms.
3 citations
TL;DR: The affection of different age rats by potassium dichromate was led to the violation of antioxidant system and it was confirmed by decrease of the catalase rate and reduced glutathione content in blood serum and liver of experimental animals.
Abstract: The affection of different age rats by potassium dichromate (3 mg/kg) was led to the violation of antioxidant system. It was confirmed by decrease of the catalase rate and reduced glutathione content in blood serum and liver of experimental animals. The most sensitive animals to the bile formation processes were immature and old animals, affected by K2Cr2O7.
2 citations
TL;DR: In this article, the synthesis, antitumor and FGFR1 inhibitory activity of novel isoindolo[2,1-a] [1,2,4]triazino [2,3-c]quinazolines was described.
Abstract: Presented manuscript describes the synthesis, antitumor and FGFR1 inhibitory activity of novel isoindolo[2,1-a] [1,2,4]triazino[2,3-c]quinazolines. It was shown that mentioned above substances may be prepared by interaction of 3-(2-amino-3-R2-5-R3-phenyl)-6-R1-1,2,4-triazin-5(2H)-ones with 2-formylbenzoic and 6-formyl-2,3-dimethoxybenzoic (opianic) acids in acetic acid. It was shown that proper 2-(2-oxo-3-R-6,7-dihydro-2H-[1,2,4]triazino[2,3-c]quinazolin- 6-yl)benzoic acids (or corresponded dimethoxysubstituted analogues) may be considered as intermediates of the reaction. Spectral properties of synthesized compounds were studied, it was shown that protons in position 8 were observed at low field as result of the presence of hydrogen bond between hydrogen at position 8 and oxygen at position 10. The anticancer assay data allowed to identify synthesized compounds as promising antitumor agents. The FGFR1 inhibitory activity of synthesized compounds was detected and docking study aimed to the evaluation of mentioned action was conducted.
2 citations
TL;DR: The aim of this work was to examine the effect of heavy metal ions and phosphororganic pestecies which contain glyphosate on activity antioxidative enzymes in the serum and liver of rats.
Abstract: The aim of this work was to examine the effect of heavy metal ions and phosphororganic pestecies which contain glyphosate on activity antioxidative enzymes in the serum and liver of rats. The effect of peptide tsysteil-histidil-tyrosil-histidil-isoleucine on the state of antioxidant protection (superoxide dismutase, catalase) and lipid peroxidation was reached. The peptide exhibits antioxidant activity, the correction of the peptide increases antioxidant enzymes activity and concentration of glutathione.
2 citations
TL;DR: The article adduces the results of the research performance of reactive oxygen in the blood and liver tissue of rats in early post-traumatic period after combined chest trauma and hips, and showed the effectiveness of the emoxipin and mexicor use in animals with combined trauma within 1 day of post- traumatic period.
Abstract: The article adduces the results of the research performance of reactive oxygen in the blood and liver tissue of rats in early post-traumatic period after combined chest trauma and hips. It was established that the post-traumatic period after combined chest trauma and both hips characterizing by increasing of free oxygen radicals percentage in the blood leukocyte suspensions and liver tissue after 1 day with advanced dynamics within 3 days of the experiment. It was showed the effectiveness of the emoxipin and mexicor use in animals with combined trauma within 1 day of post-traumatic period. Comparing the data in groups of correction antihypoxants with metabolic action revealed more expressed effect of the mexicor within 3 days of the experiment, which due to the presence of succinic acid in its composition.
2 citations
TL;DR: The long-term diet containing 2% alpha-ketoglutarate has been prevented overproduction of filament form of GFAP in the thalamus and hippocampus of older animals.
Abstract: There has been shown the change of level of astrocytes-specific glial fibrillary acid protein (GFAP) in different areas of the brain of laboratory gerbils at different stages of postnatal development, aging, and the effect of lphaketoglutarate.Studies have shown that the content of both soluble and filament forms of GFAP significantly increased during the first 30 days of postnatal development in all parts of the brain. After 30 days, the level of soluble forms of GFAP continued gradualy increase in all studied brain areas of gerbils during development and aging. Content of filament forms of GFAP in the gerbils brain after 90 days has a different tendency to change depending on the brain region. The long-term diet containing 2% alpha-ketoglutarate has been prevented overproduction of filament form of GFAP in the thalamus and hippocampus of older animals.
1 citations
TL;DR: In this article, the results of study of qualitative composition and quantitative content of hydroxycinnamic acids in the herb Stachys sieboldii Miq are presented.
Abstract: In the article the results of study of qualitative composition and quantitative content of hydroxycinnamic acids in the herb of Stachys sieboldii Miq. are presented. By the method of HPLC it was established the presence of chlorogenic, rosemarinic, caffeic and p -coumaric acids. Quantitative content of hydroxycinnamic acids was determined by the method of spectrophotometry.
1 citations
TL;DR: Analysis of indicators allows asserting that in experimental rats liver homogenate observed activation of free radical oxidation, the intensity of which depended on the concentration of stearates in water, and inhibition of antioxidant systems while under the influence of sodium stearate – its activation.
Abstract: Toxic effects of heavy metals on animals and humans is aggravating the presence of surfactants. The aim of our research was to identify the peculiarities of free radical oxidation and antioxidant protection in the use of drinking water with subtoxic doses of potassium and sodium stearates in combination with copper on the body of warmblooded animals, such as the liver of experimental rats. Analysis of indicators allows asserting that in experimental rats liver homogenate observed activation of free radical oxidation, the intensity of which depended on the concentration of stearates in water. More pronounced changes were in animals that consumed water with potassium stearate.The action of potassium stearate observed inhibition of antioxidant systems while under the influence of sodium stearate – its activation. Changes in performance were more pronounced in combination stearates with copper.
1 citations
TL;DR: Features of lipid peroxidation processes and antioxidant system in spleen tissue of white rats in experimental carcinogenesis and application of cytostatics were studied in experimental research.
Abstract: Features of lipid peroxidation processes and antioxidant system in spleen tissue of white rats in experimental carcinogenesis and application of cytostatics were studied in experimental research. In DMH-induced cancerogenesis it was found a significant increase concentration of TBA-reactive substances and lipid hydroperoxides, decrease of antioxidant enzyme activity and reduced glutathione concentration in the examined organ tissue. The combined use of chemotherapeutic drugs increased imbalance of redox processes in spleen.
TL;DR: During the late manifestations after cranio-skeletal injuries is observed violations of bile-form functions of liver, manifested by decreased of total gall acids in the bile, less of cholato-cholesterol ratio and the degree of conjugation of bilirubin.
Abstract: During the late manifestations after cranio-skeletal injuries is observed violations of bile-form functions of liver. It was manifested by decreased of total gall acids in the bile, less of cholato-cholesterol ratio and the degree of conjugation of bilirubin, which is gradually recovering from 14 to 35 days, without reaching the level of control. Applications of phytomedications accompanied by accelerated recovery biochemical composition of bile and the normalization of the most studied parameters up to 35 days.
TL;DR: The results obtained indicate to the fact that concomitant use of LIIRLR potentiates diclofenac sodium, which will allow to decrease the dose, influence on its entry and duration of its action in the organism, as well as to decreasing the frequency of drug administration.
Abstract: The aim of this study is to determine the influence of low-intensity infrared laser radiation (LIIRLR) on concentration of diclofenac sodium in the experiment on rats by the method of high-performance liquid chromatography. For study conduct, a total of 15 male rats with body weight of 250-300 gwere used. Experimental animals were subdivided into 3 groups. Animals of group 1 received diclofenac sodium per os at the dose of ED 50 (8 mg/kg of animal body weight). Animals of group 2 received diclofenac sodium per os (8 mg/kg) and in 15 min were exposed to LIIRLR. Animals of group 3 were exposed to LIIRLR and in 15 min received diclofenac sodium per os at the dose of 8 mg/kg. Animals were sacrificed in 60 min after drug administration. For extraction of diclofenac sodium from rat plasma samples, we used a method of solid-phase extraction, which had been modified due to micro-concentrations of the active substance. In the result of the studies conducted, it has been determined that therapy regimen with the following sequence is the most efficient in the animals studied: exposure of LIIRLR and administration per os of diclofenac sodium in 15 min. The results obtained indicate to the fact that concomitant use of LIIRLR potentiates diclofenac sodium. It will allow to decrease the dose, influence on its entry and duration of its action in the organism, as well as to decrease the frequency of drug administration.
TL;DR: It was found out that peptide exhibits antioxidant activity, the correction of the peptide and glutathione content.
Abstract: The reduced glutathione content and the glutathione metabolism enzymes activity in organs and blood plasma of rats under conditions of lead acetate, copper sulphate and glyphosate in Roundup form were studied. The glutathioneperoxidase, the glutathionereductase activity and the concentration of glutathione decreases during action of heavy metals and glyphosate. It was found out that peptide exhibits antioxidant activity, the correction of the peptide and glutathione content.
TL;DR: The introduction of aqueous extract from Lemna minor frond resulted in positive influence on the restructuring of the thyroid gland in rats with hypothyroidism, increasing its functional activity.
Abstract: The influence of aqueous extract from Lemna minor frond on morphological status of the thyroid gland in the experimental conditions of hypothyroidism in rats induced by administration of merkazolilum solution instead of drinking water for 30 days was studied. Thyreostatic merkazolilum resulted in changes of morphological structure of the thyroid gland, accompanied by manifestations of hyperplastic tissue proliferation and corresponds with hypofunctional state. The introduction of aqueous extract from Lemna minor frond resulted in positive influence on the restructuring of the thyroid gland in rats with hypothyroidism, increasing its functional activity. There was a decrease of proliferative processes of the epithelium and ekstrafollicular thyrocytes in follicles. The outer diameter of the follicles are not different from intact control, height follicular thyrocytes decreased compared with pathology by 41.08%. Iodomarin and L-thyroxine increased functional activity of the thyroid gland, but to a lesser degree than the aqueous extract from Lemna minor frond. L-thyroxine is not increased pharmacological effect of the studied extract. The results have practical significance for drugs development with thyroid-stimulating action.