Showing papers in "Medical Recapitulate in 2009"

Pre-pregnancy Body Mass Index and Pregnancy Weight Gain:Associations with Pregnancy Outcome

Abstract: With the increasing pregnancy obesity,the poor outcome is thought highly of a dramatic problem.This article summarized the physiology,pathological change,and the risk during gestation period,birth process,and long-term after delivery associated to the pregnancy obesity and showed that it will be better to the pregnancy obesity by controlling the weight gain or keeping invariant during the period of generation.

Small Intestinal Bacterial Overgrowth and Irritable Bowel Syndrome

Abstract: Recent studies provide increasing support for the concept that there is a association between small intestinal bacterial overgrowth(SIBO)and irritable bowel syndrome(IBS):several double-blind randomized trials describe that SIBO is more prevalent in patients with IBS vs.matched controls without IBS,and.eradication therapy is effective in reducing IBS symptoms.It is also considered that SIBO has been implicated in the pathogenesis of IBS.But these studies are far from being exhaustive and conclusive.This article reviewed recently published studies demonstrating associations between them,the pathophysiology that may be involved in,and the effect of antibiotic treatment.

Genetic Alterations in Urothelial Bladder Carcinoma

Abstract: The newly discovered oncogenes and tumor suppressor genes play an important role in the pathogenesis of urothelial bladder carcinoma,such as p53,serine threonine protein kinase 15(STK15),triple-function domain(TRIO),fragile histidine triad(FHIT),p63 genes,and alterations of 20q and 5p,alterations of adhesions,angiogenesis,and matrix-remodeling gene products and othersThis article reviewed the oncogenes and tumor suppressor genes involved in occurrence and development of urothelial carcinoma

Pharmacological Research Progress of Aralia Elata

Abstract: Aralia elata is a well-known traditional Chinese medicinal plant.There is abundant Aralia elata resource in Northeast China.Aralia elata is commonly used for treatment of cardiovascular diseases,inflammation,hepatitis,tumor,and internal and external bleeding due to injury.

Advancement on Pharmacological Action of Glycyrrhetinic Acid

Abstract: Glycyrrhetinic acid is one of the main pharmacological substances of licorice.In recent years,glycyrrhetinic acid have been found with multiple pharmacological effects,anti-tumor,anti-inflammatory,antibacterial,antivirus,anti-cardiovascular diseases,immunoregulation,anti-oxidation,and adrenal cortex-like effect,etc.Pharmacological action of glycyrrhetinic acid is reviewed in this paper accordding to the investigation of the world.

Health Related Quality of Life in Diabetic Patients

Abstract: Diabetes mellitus is a chronic disease with harms to human health.It may damage many organs and genealogies.Researchers have paid more attention on the life quality of diabetic patients.Health related quality of life has been regard as a new index of health indicator and prognosis evaluation,for it may evaluate state of diabetes and therapeutic efficacy.This article reviewed the advancement in quality of life in diabetic patients.

Mechanisms of Ventricular Arrhythmias in Heart Failure

Abstract: Heart failure is terminal phase of a variety of cardiovascular diseases.Ventricular arrhythmia in patients with heart failure is one of the major risk factors of death,the incidence of 80% to95%.At present,four major clinical types of commonly used anti-arrhythmia drugs are poor,so in-depth study of heart failure complicated by the occurrence of ventricular arrhythmia mechanisms,looking for a new anti-arrhythmic drug target for the treatment of heart arrhythmias.At present,in patients with heart failure,a number of factors that lead to abnormal cardiac electrophysiology induced arrhythmia through the trigger,automaticity,and reentry mechanism.

Postoperative Cognitive Dysfunction in Elderly Patients

Abstract: Postoperative cognitive dysfunction is a common complication of surgery,especially in elderly patientsIt usually leads to increased mortality,delayed recovery,increased other complications,prolonged duration of patients in hospital and increased cost of medical treatmentThis article reviews the incidence,risk factors and pathogenesis,diagnosis,preventive strategies and treatment of postoperative cognitive dysfunction in elderly patients

Research Progress of Epidemiology about Non-traumatic Osteonecrosis of Femoral Head

Abstract: As a frequently-occurring and refractoriness disease in orthopedic clinic,osteonecrosis of the femoral head has a long course and shy-high mutilation rate.Non-traumatic osteonecrosis of the femoral head has more complex cause,and often can not be timely diagnosed and treated.With the worsened condition,it eventually leads to hip dysfunction,and seriously impacts on quality of life.In this paper,the research progress of epidemiology about non-traumatic osteonecrosis of the femoral head was reviewed to further understand the general incidence,clear the main trend in the incidence of pathogenic factors and provide more comprehensive information for the diagnosis.

Research Advancement about Insulin Resistance of β Cells

Abstract: Both insulin resistance and islet β cell dysfunction contribute to the development of type 2 diabetes.The research confirm that Islet β cell exists insulin resistance as periphery architecture.Insulin resistance of β cell make insulin resistance and islet β cell dysfunction to connect in islet cellular level,InsR、IRS-1/-2 in the signal transduction is correlated closely with β cell function,which may be relative to the high free fatty acids,oxidative stress,and inflammatory response.Insulin resistance of β cell is crucial for the new insight into the mechanisms of insulin resistance and type 2 diabetes.

Aluminium and Alzheimer Disease

Abstract: Alzheimer′s disease(AD)is a progressive neurodegenerative disorder and the most common cause of dementia,affecting millions eldly people worldwide,which is characterized by neuritic plaque and neurofibrillary tangles pathologically.The factors associated with the onset and progression of the disease are not entirely known now,but more and more researchers considered the link between the environmental factors and the occurrence of Alzheimer′s disease in recent years,and scholars paid more attention to the metal elements such as aluminum,copper,zinc,etc.in natural environment,among which aluminum become the research focus.A lot of epidemiological evidence suggests that elevated levels of aluminum in drinking water may be linked to the development of AD,and some researcher pose the theory of β-amyloid、lipid peroxidation、cholinergic and so on,the metal chelator therapy as a potential treatment for AD is also to be discussed.In this review we will give a summary about the recerach of the Aluminium and AD rencently.

Exercise During Pregnancy:Maternal and Fetal Responses

Abstract: By doing exercises moderately,pregnant women can keep muscles in good condition and ease the discomfort during both pregnancy and delivery.In addition,the heart rates of the fetus remains normal regardless the exercises that have been performed.Moreover,exercises can increase the possibility of natural delivery and it can decrease the rate of cesarean section.Which is favorable for the post-partum recovery.Thetypes of exercises are subject to change due to the variability of health conditions of each individuals.However,one is highly recommended to consult a professional of obstetrics and gynecology before doing any kind of exercise.Thus,a proper amount of exercises can benefit the expectant mother,while do no harm to the fetus.

Combination Effect of Gene Polymorphisms in 16 Position of β_2-adenergic Receptor and Cigarette Smoking on Asthma in Chinese Han Individuals

Abstract: Objective To investigate the association of asthma with gene polymorphisms in 16 position of β2-adenergic receptor(β2-AR-16)and cigarette smoking,and its combination effect on FEV1 in asthma.Methods This was a study of the molecular epidemiology in patients with asthma.The research design was a case-control study.β2-AR-16 gene polymorphisms were detected by sequencing the specific PCR-products directly,FEV1% was measured with respiromete and smoking status was recorded in 120 asthma patients and 120 age and sex matched healthy controls.Further more the association analysis including cigarette smoking with β2-AR-16 gene polymorphisms,and FEV1 with cigarette smoking and β2-AR-16 gene polymorphisms were performed.Multiple logistic regression was used to calculate the odds ratio(OR)and the 95% confidence interval(CI)and to adjust for potential confounding factors.Results The ratio of cigarette smoking in asthma groups was higher than that in normal groups(P=0.0186).Compared with never-smoking Arg-16 homozygotes,those ever-smokers who are Arg-16 homozygotes hold a significantly increased risk of asthma[odds ratio(OR)=9.74;95% confidence interval(CI):2.07 to 43.50].This association showed a clear dose-response relationship with the number of cigarettes smoked.In never-smoking asthmas,subjects with different β2-AR-16 gene polymorphisms had different FEV1,the difference of FEV1 between each of them were significant(all P0.05),at the same times,in asthmas with different β2-AR-16 gene polymorphisms,the difference of FEV1 between smoking groups and never-smoking groups were also significant(all P0.05).Conclusion The interaction between cigarette smoking and Arg-16 homozygotes increased the susceptibility of an individual to asthma;Cigarette smoking in coordination with β2-AR-16 gene polymorphisms had impairment effect on FEV1.

Research Progress of Icariin Pharmacologic Action

Abstract: Icariin(ICA)is an active component of epimedium and is effective on cardiovascular system,renal function,genital function and immunoregulation.Icariin can increase cardiovascular and cerebrovascular blood flow.It also has the effects of kidney yang,promoting hematopoietic function,anti-thrombosis,enhancing immune function,preventing osteoporosis,anti-tumor,anti-aging and so on.This paper reviewed the pharmacological effects of ICA.

Research Progress of Leydig Cells

Abstract: Leydig cells were the main site to the synthesis and secretion of androgen(testosterone),about 95% of the androgen were synthesized and secreted by it,the study of interstitial cells were that all the male reproductive and endocrine studies can not evade.Research of Leydig cells in the field of medicine and biology were more,such as biological characteristics of the Leydig cells,allogeneil graft to supply the androgen levels in elderly men to treat partial androgen deficiency and its other reproductive role.This paper rewiewed the recent progress of Leydig cells after a great deal of related literature.

Research Development of Renal Ischemia Reperfusion Injury and Its Protective Strategies

Abstract: Ischemia-reperfusion injury is a common cause of acute renal failure and the major factor limiting the function and survival of the transplanted kidney.This article summarized the mechanistic studies on renal ischemia-reperfusion injury and clinical and laboratory explorations of protective strategies against it.

Long-term Complications of Polycystic Ovary Syndrome

Abstract: Polycystic ovary syndrome(PCOS)is the most common endocrine disorder affecting women of reproductive age and has important long-term complications.Most women with PCOS are affected by insulin resistance,and they have the increased risk suffering from type 2 diabetes about 3-7 folds.50%woman with PCOS had obesity,especially centripetal obesity.Dyslipidaemia is common among women with PCOS.Women with PCOS have increased risk for cardiovascular disease and endometrial carcinoma.

Drug Treatment of Pulmonary Hypertension

Abstract: Pulmonary hypertension is a set of clinical and pathological syndrome characterized as pulmonary arterial spasm,intimal hyperplasia and remodeling,which eventually leads to progressively increased pulmonary vascular resistance,and then right heart failure until to deathArtery type of pulmonary hypertension(PAH)is subject to the diagnosis such condition as the pulmonary artery wedge pressure below 15 mm Hg,pulmonary vascular resistance above 3 wood units and normal or lowered cardiac outputTraditional therapy has poor effect on this disease,and can not postpone its proceedingHowever,recent researches about mechanism of this diseases and exploring of new vasodilatator specifically acted on lung circulation have testified their prospective in promoting prognosisThere are many treantments,such as the application of vasodilative drugs including endothelin receptor antagonists,prostaglandin analogues,phosphodiesterase inhibitors,calcium antagonists,nitric oxide,arginine,application of anticoagulants;the treatment of right ventricular failure and improvement of the quality of life surgery and so onThis article reviews the drug treatment of pulmonary hypertension

The Roles of Vascular Endothelial Growth Factor in Hypoxic-Ischemic Cerebral Injury

Abstract: The exact mechanism is still not clear for hypoxi-ischemic cerebral injury.When oxyen is poor,the vascular endothelial growth factor(VEGF) get expressed,which was demonstrated to be associated with some factors.VEGF is a specific mitogen of endothelial cells,and a vascular permeability factor too.This article discussed the structural and biological function of VEGF,and discussed the relevant factors associated with VEGF expression and the function of VEGF in Cerebral ischemia.

Advances in Anti-tumor Effects of Ginsenoside Rg3

Abstract: Ginsenoside Rg3 is a kind of traditional Chinese herb,which can induce the apoptosis of cancer cells,inhibit the growth,adhesion,invasion,metastasis and formation of new blood vessel.The anti-invasion and anti-metastatic effects of Ginsenoside Rg3 are associated with the inhibition of intracellular Ca2+ and cancer cell invasiveness.The combination of Rg3 and chemotherapeutic agents can reduce the toxicity and increase therapeutic effects.Furthermore,it can reverse the multi-drug resistance of cancer cells,improve the human immunity,and prolong the survival duration and improve life quality of cancer patients.

Advances in the Researches of Curcumol Against Tumor

Abstract: Curcumol is one of the new anti-tumor traditional Chinese medicine monomer recently.Particularly effectivity and hypotoxicity of Curcumol has promoted its widely use in the tumor therapy.Curcumol's anti-tumor mechanism is completely unknown and may be related to apoptosis induced and cell differentiation induced,cell membrane potentials,nucleus-metabolism of tumor cell and angiogenesis inhibited.

Research Progress on Extraction,Separation and Content Determination of Betaine

Abstract: Betaine is one kind of quaternary ammonium water-soluble alkaloid which widely distributes in zoology,botany organization and microorganism.Betaine,which has many kinds of biology functions,showsgood physics and chemistry character,good stability,oxidation resistance ability,and ability of tolerance to heat,acid and alkali.There are many reports on the methods of extraction,separation and content determination of Betaine.This article mainly introduced some important methods of extraction,separation and content determination of Betaine from the beet molasses and the biological samples.This will provide powerful help for the Betaine research.

Study Progress of Oxidized Low Density Lipoprotein and Atherosclerosis

Abstract: Oxidized low density lipoprotein is a very important lipoprotein that can induce atherosclerosis,as the independent risk factor of atherosclerosis,it plays an important role in the genesis and development of atherosclerosis.It can induce the injure of vascular endothelial cell and the adhesion of monocytes and endothelial cell.It also play a part in the formation of foam cell and effecting the stability of plaque.This article reviews the study progresses of the relationship of oxidized low density lipoprotein and atherosclerosis.

Research Progress of Myocardial Fibrosis

Abstract: Myocardial fibrosis links with many clinical diseases and pathological process,such as hypertension,myocardial infarction,viral myocarditis,atherosclerosis and diabetes.Myocardial fibrosis causes heart failure,arrhythmia,sudden cardiac death and other serious complications.Prevention and reversal of myocardial fibrosis is important in clinical treatment.However,the pathogenesis of myocardial fibrosis remains unclear.Myocardial fibrosis has been found to relate with renin-angiotensin-aldosterone system,oxidative stress,inflammatory factors,growth factors,coronary endothelial dysfunction and imbalance of endothelium-derived cytokine secretion.This article reviewed study progress about the pathogenesis of myocardial fibrosis.

Estrogen Receptor α Gene Polymorphism and Endometriosis

Abstract: Estrogen receptors belong to the nuclear receptor superfamily,which is one of the most important hormone of the female reproductive system.Estrogens must binds with its receptor,and then play an important role.Gene polymorphisms of estrogen receptor α influence the expression and function of ERα.Endometriosis is an estrogen-dependent diseases,whether there is relationship between ERα gene polymorphism and Endometriosis is still in discussion.This article reviewed the ER α gene polymorphism and its relationship with endometriosis.

Application of Nanotechnology in Medicine

Abstract: The main research area of nano-biotechnology in medicine is involved in separating and staining cell,imaging technique,pathological diagnosis,tumor diagnosis,drug/gene-loaded nanoparticles and nanoparticle drugs,nanobiomaterials,nano artificial tissue,organ and so onThis article had made a summary of the application of nanotechnology in modern medicine,especially in nanomedical detection,nano-diagnosis and nano-treatment field and its research progress recentlyOn this foundation,nano-biotechnology of further development and application is proposed

Mechanism of Aspirin Resistance

Abstract: Aspirin is widely used in patients with thrombotic diseases or in high-risk group.However,part patients using aspirin can not avoid the occurrence of thrombotic diseases,the concept of "aspirin resistance" was proposed.The dosage of aspirin,overdose of epoxidase 2,effect of arachidonic acid lypoxygenase metabolic pathway,multiplicity of glucoprotein Ⅱb/Ⅲa acceptor hypotype and activating route of other thromboplastid can cause aspirin resistance,this article reviews the mechanism of aspirin resistance.

Endoplasmic Reticulum Stress and Tumor

Abstract: Endoplasmic reticulum(ER)is widely existed in eukaryotes and it has the function of both calcium storage and protein folding.Accumulation of unfolded or misfolded protein in the ER can lead to ER stress.To adapt to the occurrence of ER stress,cells activate highly conserved stress response,the endoplasmic reticulum stress(UPR).ER stress and UPR have been implicated in diabates,tumors,neurodegenerative diseases and cerebral ischemia.Thispaper reviewed the important roles of ER stress and UPR in tumor progression and provided novel avenues for potential therapies.

The Research Progress of Vasoactive Intestinal Peptide

Abstract: Vasoactive intestinal peptide(VIP)is one of the most important neurotransmitters.VIP,which has a feature of wide distribution in human tissue and partakes variform biological function,participates in information transfer and physiological regulation of the body.VIP was deeply researched in recent years.In this paper,we overview the research progress of VIP in the following aspects:biological characteristics,biological function and main physiological effects.

Pharmacological Effect and Clinical Application of Ligustrazine Injection

Abstract: The component of chinese herbal medicine is complicate,the treatment is through the multi-faceted,multi-target effect on the body′s different tissues and organs,then appear the curative effect.Ligustrazine injection is refined by modern science and technology,extracted from one active ingredient of ligustici as amide alkaloids.Clinical application has proven that Ligustrazin injection has the effects of activating blood,vasodilation,thrombolytic,scavenging free radicals,preventing calcium channel,the protection of nerve to various diseases caused to ischemia and anoxaemia of heart,brain,lung,kidney and other organizations.