Medical Science and Discovery 

About: Medical Science and Discovery is an academic journal published by Lycia Press London UK. The journal publishes majorly in the area(s): Medicine & Internal medicine. It has an ISSN identifier of 2148-6832. It is also open access. Over the lifetime, 640 publications have been published receiving 537 citations. The journal is also known as: MSD.

Antibacterial Activity of Laurus nobilis: A review of literature

Abstract: The presence of phenolic compounds in spices and herbs, along with the essential oils, has been gaining attention due to their various functions like antioxidant capacity, antimicrobial properties, and flavoring properties. The Bay leaf belongs to Lauraceae family and is endemic in the Mediterranean region. Lauraceae , is an aromatic plant frequently used as a spice in Mediterranean cookery and as a traditional medicine for the treatment of several infectious disease. L. nobilis also belongs to Lauraceae. L. nobilis is aromatic tree, and is 2 m to 10 m high. L.nobilis contains about 1.3% essential oils and polar flavonoids mono, sesquiterpenes, alkoloids, glycosylated flavor-noids, megastigmane and phenolic components. It is known to have various pharmacological effects, including antimicrobial, cytotoxic and immune modulating. Its’ essential oil containg eucalyptol, α-terpinyl acetate, linalool, methyl eugenol, sabinene and carvacrol. The property of every essential oil varies according to the harvest country, altitude, period of sunshine, conditions of harvest. These essential oil contents of L. nobilis are strong antibacterial activity against Gram negative and Gram positive foodorne pathogens ( Salmonella , Staphylococcus aureus, Esherichia coli, Listeria monocytogenes like that), spoilage bacteria ( Pseudomonas aeroginosa ) as well as antifungal effects. The synergy between terpenes (linalool), lactones, oxides (1,8 cineole) and monoterpenes (camphene, alpa-pinene) gives to the essential oil of Laurel a good antibacterial activity. Its essential oils’ various or single chemical compositions at different concentrations have different inhibition mechanisms that can affect a variety of pathogens by changing membrane permeability, denaturing proteins and inhibiting enzymes. The oils are not affecting on existing beneficial intestinal bacteria.

Effects of oleic acid

Abstract: Content of fatty diet plays a significant role in the development and progression of chronic diseases. Generally, it is accepted that unsaturated fatty acids are beneficial. According to literature review, oleic acid (C18:1n-9) has positive impacts on various tissues in general and has negative impacts rarely. Olive oil composition includes high amount oleic acid. Considering of the effects of oleic acid on the cardiovascular system, it was determined that decreasing of the myocardial infarction rate, platelet aggregation and secretion of TXA2, plus reduce of the systolic blood pressure. LDL cholesterol was decreased. In terms of effects on the liver, while some studies suggest that oleic acid has beneficial effects, unlike other studies proved that exposed to oleic acid of hepatocytes induce ER (endoplasmic reticulum) stress in long - term period. The several studies which were investigating the efficacy of the oleic acid on the tumor tissue proved that OA increased to hepato-tumorigenesis in vivo as a potential. On te other hand, another research showed that oleic acid blocked the action of HER-2 / neu oncogene that led to breast cancer. Although some researchers reported that OA develop neutrophil phagocytic capacity and candidacidal activity, other researchers point out that these fatty acids didn’t cause any changes on bactericidal activity and fatty acids caused moderate decreases on phagocytosis and chemotaxis only in extremely high concentrations, and they suppressed to T lymphocytes. Although, most of studies have indicated to beneficial effects of oleic acids, also the adverse effects of oleic acid have been reported in a few studies. This situation requires further researches for detail information about oleic acid

The Evolution of COVID-19 Publications in Pediatrics: A Bibliometric Analysis with Research Trends and Global Productivity

Abstract: Objective: Despite the increase in the number of global studies on COVID-19 that has been increasingly contagious among children, no comprehensive bibliometric studies have been found in the literature concerning COVID-19 in pediatrics. This study aimed to perform a holistic analysis of the scientific outputs about COVID-19 in pediatrics using various statistical methods. Methods: The articles published in the research area of pediatrics on COVID-19 between January 1st, 2020 and February 13th, 2022 were downloaded from the Web of Science (WoS) and analysed using various statistical methods. Spearman's correlation analysis was performed for related research. Bibliometric network visualization diagrams were generated to reveal trending topics and cross-country collaborations. Results: A total of 5315 publications were found. Among these publications, 47.7% (n=2540) were articles. The top 5 contributors to the literature were the USA (955), Italy (278), the UK (219), Turkey (148), and China (137). The top 3 most productive institutions were Harvard University (n=107), the University of California System (n=85), and the University of London (n=75). The top 3 journals with the highest number of articles were Frontiers in Pediatrics (n=163), Pediatric Infectious Disease Journal (n=121), and Pediatrics (n=106). The top 3 most effective journals based on the mean number of citations per article were Pediatria i Medycyna Rodzinna, Lancet Child Adolescent Health, and JAMA Pediatrics. Conclusion: Topics studied on COVID-19 in pediatrics in recent months were screen time, sleep, physical activity, Type 1 diabetes, obesity, vaccine, neonatology, congenital heart disease, qualitative research, school closure, and pediatric emergency medicine.

Anxiety and Depression Differences Between the Nurses Working at a COVID-19 Pandemic Hospital:

Abstract: Objective: To investigate anxiety and depression differences between the nurses working at a COVID-19 pandemic hospital in Turkey. Material and Methods: A quantitative approach using a survey was applied. There were 331 nurses recruited by convenience sampling. Results: Females have higher anxiety scores at a significant level (p=0.017). It was also found that nurses who have family members with chronic disease have higher depression scores than nurses who do not have at a significant level (p=0.376). Similarly, nurses who have elderly family members have higher depression and anxiety scores than nurses who do not have at a significant level (p=0.008). There was a significant difference between the nurses providing and not providing COVID-19 care for depression scores (p=0.002). Conclusion: This study explores nurses’ depression and anxiety levels. Even though this phenomenon has already been studied, the outbreak of COVID-19 draws more attention to health workers and especially nurses who are part of the pandemic context. Nurses who provide COVID-19 care have higher depression and anxiety scores. Nurses who help patients to recover from COVID-19 should be in functional mental status. Thus, governments, health organizations, and hospital administrations should take adequate steps to reduce nurses’ depression and anxiety to sustain a healthy world.

Complexion of Boric Acid with 2-Deoxy-D-glucose (DG) as a novel boron carrier for BNCT

Abstract: Objective: Boron neutron capture therapy (BNCT) is an intensive research area for cancer researchers. Especially the side effects and inabilities of conventional therapies in some cases, directs researchers to find out a new cancer therapy methods such as BNCT. One of three important problem of BNCT is targeting of boron to tumor tissue. Borono Phenyl Alanine (BPA) and Borono Sodium Borocaptate (BSH) are already using in clinical studies as boron carriers. New boron carriers are searching for high yield boron accumulation in the tumor tissue. Methods: In this study, a novel 10B carrier was synthesized, ((2R)-4,5,6-trihydroxy-2-(hydroxymethyl)tetrahydro-2H-pyran-3-yl)boronic acid ( 10B-DG), for BNCT studies. 10Boric Acid and 2-Deoxy-d-Glucose was complexed ( 10B-DG) through a low-high pH reaction and yield of complexion was tested with FTIR ATR and Liquid Chromatography Mass Spectrometry (LC/MS). Results: Confirmation studies have been carried out by HPLC and chromatograms have confirmed that Borono-2-Deoxy-d-Glucose synthesized with % 80 yield. Conclusions: This compound appears to be an alternative boron carrier for BNCT applications