Showing papers in "Pharmazie in 1995"

Effect of dissolution profile and (-)-α-bisabolol on the gastrotoxicity of acetylsalicylic acid

Abstract: The effect of particle size and (-)-α-bisabolol on the gastric toxicity produced by acetylsalicylic acid (AAS) was studied in rats AAS crystals of size 05-04, 02-005 mm and AAS pellets were administered orally (dose 200 mg/kg) to rats The effect of particle size on gastric toxicity was not significant (P < 005) Small AAS crystals (02-005 mm) were granulated with ethanol to produce pellets (05-04 mm) The resultant pellets were less ulcerogenic than AAS crystals (P < 005) The pelletization process improves the wetting process of AAS crystals and for this reason produces a faster dissolution profile of AAS When (-)-α-bisabolol, a natural essential oil obtained from camomile oil, was administered orally (dose 08-80 mg/kg) with AAS (dose 200 mg/kg), a significant (P < 005) protective effect was found Some possible mechanisms of protection are suggested for (-)-α-bisabolol