Showing papers in "PLOS ONE in 2004"

Traumatic brain injury

Abstract: Quantitative strategies have been developed to evaluate the effects of posttraumatic temperature on patterns of neuronal vulnerability in models of traumatic brain injury (TBI) (Table 1) In a model of parasagittal fluidpercussion (F-P) brain injury in which brain temperature was selectively reduced (30°C) for 3 h starting 5 min after TBI, posttraumatic hypothermia (30°C) significantly decreased contusion volume and reduced the frequency of damaged cortical neurons [5] In a controlled cortical impact model in rats, mild hypothermia (32°–33°C) initiated 30min before trauma and continued for 2 h decreased contusion volume at 14 days [2, 8] In a model of diffuse TBI coupled with hypoxia and hypotension, Yamamoto and colleagues [9] reported that moderate hypothermia (30°C) initiated 15 min after injury and maintained for 60 min provided almost complete protection against secondary insults In contrast, posttraumatic hypothemia (32°C/2 h) failed to reduce volumes of necrotic tissue cavitation after cortical impact injury [6]