Razi Journal of Medical Sciences 

About: Razi Journal of Medical Sciences is an academic journal. The journal publishes majorly in the area(s): Public health & Aerobic exercise. Over the lifetime, 1087 publications have been published receiving 3749 citations.

Gene therapy approaches to regenerating the musculoskeletal system

Abstract: Injuries to the musculoskeletal system are common, debilitating and expensive. In many cases, healing is imperfect, which leads to chronic impairment. Gene transfer might improve repair and regeneration at sites of injury by enabling the local, sustained and potentially regulated expression of therapeutic gene products; such products include morphogens, growth factors and anti-inflammatory agents. Proteins produced endogenously as a result of gene transfer are nascent molecules that have undergone post-translational modification. In addition, gene transfer offers particular advantages for the delivery of products with an intracellular site of action, such as transcription factors and noncoding RNAs, and proteins that need to be inserted into a cell compartment, such as a membrane. Transgenes can be delivered by viral or nonviral vectors via in vivo or ex vivo protocols using progenitor or differentiated cells. The first gene transfer clinical trials for osteoarthritis and cartilage repair have already been completed. Various bone-healing protocols are at an advanced stage of development, including studies with large animals that could lead to human trials. Other applications in the repair and regeneration of skeletal muscle, intervertebral disc, meniscus, ligament and tendon are in preclinical development. In addition to scientific, medical and safety considerations, clinical translation is constrained by social, financial and logistical issues.

Sleep Parameters and the Factors Affecting the Quality of Sleep in Patients Attending Selected Clinics of Rasoul-e-Akram Hospital

Abstract: Background & Aim: Almost any medical illness that causes significant pain or discomfort may negatively affect the quality of sleep. Illnesses affecting cardiovascular, respiratory, gastrointestinal, and nervous systems and injuries disrupt the quality of sleep. The objective of this study is to investigate the parameters of sleep and the factors affecting the quality of sleep in medically ill patients. Patients and Method: In a descriptive cross-sectional study, a total of 300 medical patients with various somatic complaints who attended internal, ENT, orthopedic, neurology, urology and surgery clinics were selected. The assessment instrument was Pittsburgh Sleep Quality Index(PSQI) which measures the quality of sleep in 7 major domains. A score of >5 is considered as a significant sleep disturbance. The data were analyzed using descriptive statistics and one-way