Patent
5-isoquinolinesulfonic acid amide derivative
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TLDR
In this article, the authors proposed a new compound for protein phosphorylation that can be produced by reacting a compound of formula IV with a compound R NH2 (R is group of formula V, etc.) in a solvent (e.g. dichloromethane) at -30 to +100 deg.C.Abstract:
PURPOSE:To provide a new compound inhibiting a protein phosphorylation enzyme and exhibiting various pharcologic actions. CONSTITUTION:The compound of formula I (R is NHCH2CH2R , group of formula II, formula III, etc.; R is morpholin-1-yl, 2-chlorobenzylamino, etc.), e.g. 5-(2-morpholinoethylaminosulfonyl)isoquinoline. The compound of formula I can be produced by reacting a compound of formula IV with a compound of the formula R NH2 (R is group of formula V, etc.) in a solvent (e.g. dichloromethane) in the presence of an acid acceptor (e.g. triethylamine) at -30 to +100 deg.C. (2-Aminoethyl)morpholine is an example of the compound of the formula R NH2 and the amount of the compound is 1-5 equivalent based on the compound of formula IV.read more
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