Figure 3 A) Dose-dependent reduction of IBa by halothane. Halothane was applied successively at 1, 2 and 4% to a single LYC neuron with washes in between. Peak current was monitored and standard I−V pulse protocols were run during the plateau of maximal drug response. Superimposed currents represent IBa(max), measured as −8mV in this instance for both the control and test conditions. B) Time course of peak and end-pulse IBa currents recorded from an LYC during a typical experiment in response to unitary 70 ms depolarising pulses to −0mV from a holding potential of −70mV. Halothane was introduced at the concentration and duration indicated by horizontal bars.
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