A critical study of the various methods employed for enumerating blood platelets.
TLDR
The two chief characteristics of the blood platelets are their marked tendency to undergo speedy dissolution in shed blood and their property of adhering to one another and to foreign objects which explain the difficulties that have been experienced in attempts to count accurately the number of platelets.Abstract:
The two chief characteristics of the blood platelets are their marked tendency to undergo speedy dissolution in shed blood and their property of adhering to one another and to foreign objects. These characteristics explain the difficulties that have been experienced in attempts to count accurately the number of platelets. The early investigators used various preserving fluids in their attempts to prevent the disappearance of the platelets from freshly drawn blood, and the counts were made with the ordinary hematocytometer. The results were regarded as so unsatisfactory by Halla 1 that he concluded from his study that it was impossible to determine the absolute number of blood platelets, and that the relative number could be estimated best in fresh preparations. Only a few years ago Turck 2 employed the same procedure, evidently because he regarded even the newer methods of counting the platelets as quite untrustworthy. The investigations of Eberth andread more
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The Relation of Blood Platelets to Hemorrhagic Disease: Description of a Method for Determining the Bleeding Time and Coagulation Time and Report of Three Cases of Hemorrhagic Disease Relieved by Transfusion
TL;DR: Three cases and experiments are reported which furnish additional evidence to show that the blood platelets play a part in stopping hemorrhage, and that one type of hemorrhagic disease may be attributed to an extreme reduction in the number of platelets.
Journal ArticleDOI
An improved method for counting blood platelets
H. Maynard Rees,E. E. Ecker +1 more
TL;DR: After experimenting with the anticoagulants of the foregoing methods, it is reached that sodium citrate is by far the most efficient in preventing clumping of the platelets.
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Causes of variation in the platelet count: experimental results showing the effect of diphtheria toxin, benzol and tuberculin on the platelet count in rabbits
TL;DR: Differences of opinion respecting the pathologic changes in the count are largely due to the fact that the count may be enormously increased or decreased by the action of the same agents.
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Quinine and ergot allergy and thrombocytopenic purpura: report of a case
TL;DR: It is well to recall that there is also a number of conditions in which purpura occurs in the absence of a general hemorrhagic tendency and diminution of platelets, and these purpuras according to Christian can be classified into essential (idiopathic) and secondary (symptomatic) nonthrombocytopenic purpURA.
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A new method of counting the blood-platelets for clinical purposes: and some of the results obtained with it
TL;DR: A new method for estimating the number of blood-platelets per cubic millimeter of blood is devised, and the specially thin cover-glass of Zeiss, with central excavation, is used to render the platelets more clearly visible.