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All figures (4)
Table 1. Literature review on 3-hydroxypropionate (3-HP) and acrylic acid (AA) production yields by 117 the glycerol pathway in metabolically engineered Escherichia coli, and comparison with the yields 118 predicted by the dynamic models using the same initial carbon concentration. 119
Table 3. Literature review on 3-hydroxypropionate (3-HP) production yields by the β-alanine pathway 185 in metabolically engineered Escherichia coli, and comparison with the yields predicted by the dynamic 186 models using the same initial carbon concentration. 187
Table 4. Summarised results of acrylic acid production for the mutant strains developed for the 250 glycerol, malonyl-CoA, and β-alanine models, using 10 g/L of glucose as substrate. 251
Fig 1. Biosynthetic pathways for acrylic acid (AA) production from Glucose using 3-70 hydroxypropionate (3-HP) as an intermediary. 71 3-HP can be produced from Glucose through three distinct pathways: glycerol (red arrows), malonyl-72 CoA (green arrows), and β-alanine (blue arrows). Furthermore, E. coli can also direct Glycerol towards 73 the central carbon metabolism, allowing it to be used as a carbon source. 74
Posted Content
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DOI
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A kinetic model of the central carbon metabolism for acrylic acid production in Escherichia coli
[...]
Alexandre S. Oliveira
1
,
Joana Lúcia Lima Correia Rodrigues
1
,
Eugénio C. Ferreira
1
,
Lígia R. Rodrigues
1
,
Oscar Dias
1
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+1 more
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Institutions (1)
University of Minho
1
15 May 2020
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bioRxiv