Figure 3. The sup-35/pha-1 N2 haplotype is derived and is marked by an inversion. (Left) A gene tree built from the coding region of Y48A6C.4 in 152 C. elegans isolates and four other Caenorhabditis species. DL238, QX1211 and ECA36 cluster together in a separate branch from all other C. elegans isolates. (Right) The synteny in the region containing the sup-35/pha-1 element, as well as three highly conserved genes in the close vicinity (hmt-1, Y48A6C.4, and Y47D3A.29) is schematically represented. (ψ) denotes alleles that are pseudogenized. The genes sup-35 (red) and Y48A6C.4 (white) are inverted in DL238, QX1211, and ECA36 relative to the other 149 C. elegans isolates. The gene order and orientation of hmt-1, Y48A6C.4, and Y47D3A.29 in other Caenorhabditis species suggests that the inverted haplotype is the ancestral, and that the haplotype found in 149 isolates is the derived one.
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