A Novel Three-Component Tandem Protocol for the Regioselective Synthesis of 1-(2-Arylmethyl-5-aryl-3-thienyl)pyrrolidines and -piperidines

TLDR: A series of substituted 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines were synthesized by one-pot, three-component tandem reactions of 5-aryldihydro-3(2 H )-thiophenone, aromatic aldehydes and pyrrolidine/piperidine under solvent-free microwave irradiation as mentioned in this paper.

Abstract: A series of new substituted 1-(2-arylmethyl-5-aryl-3-thienyl)pyrrolidines and piperidines were synthesised by one-pot, three-component tandem reactions of 5-aryldihydro-3(2 H )-thiophenone, aromatic aldehydes and pyrrolidine/piperidine under solvent-free microwave irradiation. This facile transformation occurs presumably via a tandem enamine formation–carbonyl addition–dehydration–isomerisation sequence.