A process for the manufacture of dispersible granulates

TLDR: Granulated animal feed supplements as discussed by the authors are made by reducing to a ground mixture a raw material containing at least one active therapeutic and/or nutritive ingredient normally adversely affected by the influence of light, air or atmospheric agents, mixing and homogenizing the ground mixture, and wetting the homogenized raw material with an organic solvent containing dissolved polyvinyl pyrrolidone, n-lowryl sulphates, dioctyl sodium sulphasuccinates, alginates and polyethylene glycols.

Abstract: 1,216,349. Granulated animal feed supplements. L. P. TORT. 21 Dec., 1967 [21 Dec., 1966; 19 Dec., 1967], No. 58199/67. Headings A2B and A2E. [Also in Division A5] Granulates suitable for administration to animals in drinking liquid are made as follows: (a) reducing to a ground mixture a raw material containing at least one active therapeutic and/or nutritive ingredient normally adversely affected by the influence of light, air or atmospheric agents; (b) mixing and homogenizing the ground mixture; (c) wetting the homogenized raw material with an organic solvent containing dissolved polyvinyl pyrrolidone, n-lowryl sulphates, dioctyl sodium sulphasuccinates, alginates and/or polyethylene glycols, whereby to form a paste; (d) granulating the paste; (e) removing the solvent from the dry granules; and (f) sieving the dry granules to separate fine materials. Materials: minerals, vitamins, amino acids, antibiotics and hormones. Solvents: methanol, ethanol, isopropanol, acetone, benzene, dioctane and toluol. Granulation may be effected through a 20 mesh sieve. Final sieving is through a 16 mesh sieve. The Examples are directed to making granulates from formulations composed of: (1) specified vitamins, glucose, monosodium glutamate, sorbic acid, yellow dye, polyvinyl pyrrolidone and isopropyl alcohol; (2) specified vitamins, copper sulphate, cobalt sulphate, magnesium citrate, magnesium glycero phosphate, iron saccharate, sodium selenite, zinc chloride, glucose, glutannic acid, sorbic acid, polyvinyl pyrrolidone and isopropyl alcohol; (4) 1-(4-amino-2n-propyl-5- pyridy methyl)- 2 - pyrroline, sulphadimethylpyrimidine, Vitamin K, magnesium sulphate, dextrose, polyvinyl pyrrolidone and organic solvent; and (5) phenothiazine, piperazine citrate, magnesium sulphate, polyvinyl pyrrolidone and organic solvent.