Journal ArticleDOI
A quantitive study of the toxicity and efficiency of picrotoxin
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This article is published in Journal of the American Pharmaceutical Association.The article was published on 1938-04-01. It has received 3 citations till now. The article focuses on the topics: Picrotoxin.read more
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The picrotoxin-barbiturate antagonism: clinical observations
TL;DR: Picrotoxin, until recently a drug having experimental interest only, gained the attention of clinicians as a result of the studies of Tatum, Maloney, Koppanyi, and others, and was encouraged to use it in human beings.
Journal ArticleDOI
Action of central nervous system stimulant and depressant drugs in the intact animal: Part 3. Dual action of 5-ethyl-5-(1,3-dimethylbutyl)barbiturate, dilantin and β-methyl-β-ν-propylglutarimide
A. Shulman,Glenda M. Laycock +1 more
TL;DR: In this article, the stimulant and depressant central actions of sodium 5-ethyl-5- (1, 3-dimethylbutyl) barbiturate and sodium 5,5-diphenylhydantoinate (Dilantin) have been studied quantitatively in the mouse by titration against the analeptic (agonist) bemegride (β-methyl-β-ethylglutarimide), the partial agonist β-methyl,β-ν-propylglutaramide, and the hypnotics (antagonists) β-
Journal ArticleDOI
Action of central nervous system stimulant and depressant drugs in the intact animal: Part 1. Titration of analeptics by pentobarbitone sodium and hydroxydione
A. Shulman,Glenda M. Laycock +1 more
TL;DR: In this paper, the hypnotics pentobarbitone sodium and hydroxydione have been titrated by the analeptics bemegride, diethadione, pentylenetetetrazol, picrotoxin, s-spirocyclopentaneglutarimide and strychnine hydrochloride using hypnosis in 50 per cent of a group of mice as the titration end point.
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Picrotoxin in the treatment of barbiturate poisoning: report of case
TL;DR: Picrotoxin was discovered by Boulay in 1812 but it was not until 1847 that a rational use for it was suggested by Tschudi, when he expressed the opinion that it might be a suitable antagonist to morphine.