Journal ArticleDOI
Blindness, Dancing Extremities, and Corpus Callosum and Brain Stem Involvement: An Unusual Presentation of Fulminant Subacute Sclerosing Panencephalitis
TLDR
Pediatricians need to be aware that necrotizing chorioretinitis in a child and/or atypical brain stem changes could be the heralding feature of this condition in endemic countries.Abstract:
A 4-year-old girl presented with acute visual loss followed 2 weeks later with loss of speech and audition, fulminant neuroregression, and choreo-athetoid movements of extremities. Fundus showed bilateral chorioretinitis. Electroencephalography showed periodic complexes. Measles antibody titers were elevated in both serum and cerebrospinal fluid, consistent with subacute sclerosing panencephalitis. Neuroimaging showed discontiguous involvement of splenium of the corpus callosum and ventral pons with sparing of cortical white matter. Our case highlights the atypical clinical and radiologic presentations of subacute sclerosing panencephalitis. Pediatricians need to be aware that necrotizing chorioretinitis in a child and/or atypical brain stem changes could be the heralding feature of this condition in endemic countries.read more
Citations
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Journal ArticleDOI
Subacute sclerosing panencephalitis.
Ravindra Kumar Garg,Anita Mahadevan,Hardeep Singh Malhotra,Imran Rizvi,Neeraj Kumar,Ravi Uniyal +5 more
TL;DR: Subacute sclerosing panencephalitis (SSPE) is a slowly progressive brain disorder caused by mutant measles virus that affects younger age groups and a universal vaccination against measles is the only proven way to tackle this menace currently.
Journal ArticleDOI
Subacute sclerosing panencephalitis presenting as acute cerebellar ataxia and brain stem hyperintensities.
Arushi Gahlot Saini,Naveen Sankhyan,Hansashree Padmanabh,Jitendra Kumar Sahu,Sameer Vyas,Pratibha Singhi +5 more
TL;DR: It is highlighted that subacute sclerosing panencephalitis can present atypically as isolated acute cerebellar ataxia and peculiar involvement of longitudinal and sparing of transverse pontine fibres in children, especially in the endemic countries.
Journal ArticleDOI
Subacute Sclerosing Panencephalitis Presenting as Choreoathetosis and Basal Ganglia Hyperintensities.
TL;DR: A 10-year-old boy with subacute sclerosing panencephalitis presenting with generalized choreoathetosis, myoclonus, and cognitive decline is discussed, highlighting that atypical clinical and radiological features of subacuteness should always be borne in mind in children from endemic areas.
Journal ArticleDOI
Altered white matter integrity in patients with monocular blindness: A diffusion tensor imaging and tract-based spatial statistics study.
Yu-Xin Liu,Biao Li,Kang-Rui Wu,Li-Ying Tang,Qi Lin,Qing-Hai Li,Qing Yuan,Wen-Qing Shi,Rong-Bin Liang,Qian-Min Ge,Yi Shao +10 more
TL;DR: In this article, diffusion tensor imaging (DTI) and tract-based spatial statistics (TBSS) were used to investigate abnormal structural changes in the white matter (WM) of patients with monocular blindness (MB).
References
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Journal ArticleDOI
The Variable Natural History of Subacute Sclerosing Panencephalitis: A Study of 118 Cases From the Middle East
TL;DR: A variable natural history was found in a standardized follow-up study of 118 patients with subacute sclerosing panencephalitis (SSPE) and only 20% followed the sequence:behavior change, mental deterioration, periodic attacks, severe debility, and death within a year.
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Subacute sclerosing panencephalitis.
TL;DR: There is no effective treatment to completely cure SSPE, but Oral isoprinosine and intrathecal or intraventricular alpha-interferon may prolong survival to some extent.
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MRI findings in subacute sclerosing panencephalitis
TL;DR: Although cortical and subcortical lesions have some correlation with clinical findings, the extent and location of the periventricular white matter lesions and cerebral atrophy did not reflect the neurologic status in many patients.
Journal ArticleDOI
Subacute sclerosing panencephalitis: Correlation of clinical, neurophysiologic and neuropathologic findings
TL;DR: Clinical, neurophysiologic and neuropathologic findings were correlated in five cases of subacute sclerosing panencephalitis, indicating relative preservation of the cortex in the early stages of the disease.
Journal ArticleDOI
Subacute Sclerosing Panencephalitis Manifesting as Viral Retinitis: Clinical and Histopathologic Findings
Donald W. Park,H. Culver Boldt,Stephen J. Massicotte,Effiong E. Akang,Karen L. Roos,Adriana Bodnar,John Pless,Bernardino Ghetti,Robert M. Pascuzzi +8 more
TL;DR: This case is unusual in that the patient developed subacute sclerosing panencephalitis later in life and because there was an 8-year period between presumed viral infections in the two eyes.